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CAM-Related/Down-Regulated by Oncogenes (CDON) Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS602810

Mouse CDO is a 190kD member of the Ig/FN-type III repeat subfamily of transmembrane proteins. The extracellular region contains five Ig-like domains and three FN-III modules. The molecule forms cis-complexes with itself and the related molecule termed BOC.… More details

$955 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CAM-related/Down-regulated by Oncogenes (Cdon), Monoclonal Antibody
Full Product Name
CAM-related/Down-regulated by Oncogenes (Cell Adhesion Molecule-related/Down-regulated by Oncogenes, CDO)
Product Gene Name
anti-Cdon antibody
Product Synonym Names
Anti -CAM-related/Down-regulated by Oncogenes (Cell Adhesion Molecule-related/Down-regulated by Oncogenes, CDO)
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
8H134
Host
Rat
Species Reactivity
Mouse
Form/Format
Supplied as a lyophilized powder in PBS with 5% trehalose. Reconstitution: Reconstitute with 200ul sterile 40-50% glycerol, PBS.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes mouse CDO.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol, PBS and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
135,422 Da
Chromosome Location
Chromosome: 9; NC_000075.5 (35259661..35315237). Location: 9 A4; 9
3D Structure
ModBase 3D Structure for Q32MD9
Immunogen
NS0-derived rmCDO extracellular domain.

Product Categories/Family for anti-Cdon antibody

Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-Cdon antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Cdon antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1-2ug/ml with the appropriate secondary reagents to detect mouse CDO. Using a colorimetric detection system, the detection limit for rmCDO is approximately 5 ng/lane under non-reducing and reducing conditions. Chemiluminescent detection will increase sensitivity by 5 to 50 fold.
ELISA (direct): 0.5-1.0ug/ml with the appropriate secondary reagents to detect mCDO. The detection limit for rmCDO is approximately 1ng/well.

Other Notes

Small volumes of anti-Cdon antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cdon purchase

MBS602810 is an antibody targeting Cdon. Also known as CAM-related/Down-regulated by Oncogenes (Cell Adhesion Molecule-related/Down-regulated by Oncogenes, CDO). Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for Cdon. It may not necessarily be applicable to this product.

NCBI GI #
160333799
NCBI GeneID
57810
NCBI Accession #
NP_067314.2
UniProt Primary Accession #
Q32MD9
UniProt Secondary Accession #
O88971; E9QKV9
UniProt Related Accession #
Q32MD9; Q3TZM7; Q8CE17
GenBank Nucleotide #
NM_021339.2
NCBI Official Full Name
cell adhesion molecule-related/down-regulated by oncogenes
NCBI Official Synonym Full Names
cell adhesion molecule-related/down-regulated by oncogenes
NCBI Official Symbol
Cdon
NCBI Official Synonym Symbols
CDO; Cd0; Orcam; MGC129383
UniProt Protein Name
Cell adhesion molecule-related/down-regulated by oncogenes
Protein Family
Cell adhesion molecule-related/down-regulated by oncogenes
UniProt Gene Name
Cdon
UniProt Synonym Gene Names
Cdo
UniProt Entry Name
CDON_MOUSE
NCBI Protein Information
cell adhesion molecule-related/down-regulated by oncogenes; OTTMUSP00000040005; immunoglobulin superfamily member CDO; CAM-related/down-regulated by oncogenes; oncogene-regulated cell adhesion molecule

UniProt Comments for Cdon

CDON: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Defects in CDON are the cause of holoprosencephaly type 11 (HPE11). HPE11 is a structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion

Cellular Component: cell surface; membrane; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: protein binding

Biological Process: lens development in camera-type eye; regulation of protein heterodimerization activity; smoothened signaling pathway; regulation of neuron differentiation; satellite cell differentiation; cell fate specification; positive regulation of skeletal muscle development; positive regulation of myoblast differentiation; anterior/posterior pattern formation; positive regulation of small GTPase mediated signal transduction; cell-cell adhesion; embryonic body morphogenesis; positive regulation of MAPKKK cascade; embryonic retina morphogenesis in camera-type eye; striated muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; embryonic morphogenesis; cerebral cortex development; positive regulation of neuron differentiation; cell adhesion; myoblast fusion; regulation of striated muscle development
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Research Articles on Cdon

1. The promyogenic function of Cdo involves a coordinated activation of p38MAPK and Akt via association with scaffold proteins, JLP and Bnip-2 for p38MAPK and APPL1 for Akt.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Cdon antibody

 Products by Pathway  Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 Myogenesis Pathway antibodies  Myogenesis Pathway Diagram

Diseases associated with anti-Cdon antibody

 Disease Name  Pubmed Publications
 Craniofacial Abnormalities Antibodies  >3 publications with Cdon and Craniofacial Abnormalities
 Congenital Abnormalities Antibodies  >3 publications with Cdon and Congenital Abnormalities
 Musculoskeletal Abnormalities Antibodies  >3 publications with Cdon and Musculoskeletal Abnormalities
 Abnormalities, Multiple Antibodies  >2 publications with Cdon and Abnormalities, Multiple
 Nervous System Malformations Antibodies  >2 publications with Cdon and Nervous System Malformations
 Rhabdomyosarcoma Antibodies  >1 publications with Cdon and Rhabdomyosarcoma
 Hydrocephalus Antibodies  >1 publications with Cdon and Hydrocephalus
 Bone Diseases, Developmental Antibodies  >1 publications with Cdon and Bone Diseases, Developmental

Organs/Tissues associated with anti-Cdon antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >10 publications with Cdon and Muscle
 Other Antibodies  >5 publications with Cdon and Other
 Embryonic Tissue Antibodies  >4 publications with Cdon and Embryonic Tissue
 Eye Antibodies  >2 publications with Cdon and Eye
 Lung Antibodies  >1 publications with Cdon and Lung
 Brain Antibodies  >1 publications with Cdon and Brain
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