Factor XII Light Chain Antibody – Mouse Monoclonal

Human Factor XII (XII) (Hageman Factor) is a single chain (78kD) glycoprotein zymogen that circulates in plasma at a concentration of 40 mg/ml. Reciprical activation of XII to the active serine protease factor XIIa (XIIa) by kallikrein is central to initiation of the intrinsic coagulation pathway. Surface bound a-XIIa in turn activates factor XI to XIa. A single cleavage by kallikrein at R353-Val354 of XII yields a-XIIa, a 2 chain protease (80kD) held together by disulfide bonds. The COOH-terminal light chain (28kD) contains the catalytic triad (His-40, Asp-89, Ser-191), while the NH2-terminal heavy chain (52kD) conatins the anionic surface binding portion of the molecule. A secondary cleavage of a-XIIa by kallikrein outside the disulfide bond yields b-XIIa (XIIf, BHFa, HFf, hageman factor fragments) (28kD), which no longer binds anionic surfaces. b-XIIa can activate prekallikrein, but has little procoagulant activity.

Small volumes of anti-Factor XII Light Chain antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS602874 is an antibody targeting Factor XII Light Chain. Also known as Factor XII Light Chain (Hageman Factor). Reactive in Human. Host: Mouse.