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Calcyclin Binding Protein (CACYBP) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS602942

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and… More details

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Product Overview

Online Datasheet in PDF
Product Name
Calcyclin Binding Protein (CACYBP), Monoclonal Antibody
Full Product Name
Calcyclin Binding Protein (CACYBP, GIG5, MGC87971, PNAS-107, RP1-102G20.6, SIP, S100A6BP)
Product Gene Name
anti-CACYBP antibody
Product Synonym Names
Anti -Calcyclin Binding Protein (CACYBP, GIG5, MGC87971, PNAS-107, RP1-102G20.6, SIP, S100A6BP)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
8C53
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide, before the addition of glycerol to 40%.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human Calcyclin Binding Protein. Species Crossreactivity (WB): mouse, rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
26,210 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (174968571..174981163). Location: 1q24-q25
3D Structure
ModBase 3D Structure for Q5R371
Immunogen
Partial sequence of recombinant full-length protein to human Calcyclin Binding Protein

Product Categories/Family for anti-CACYBP antibody

Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-CACYBP antibody
Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)
Application Notes for anti-CACYBP antibody
Suitable for use in Flow Cytometry, Western Blot and Immunocytochemistry.
Dilution: Flow Cytometry: 0.5-2ug
Western Blot: 0.2-2ug/ml
Immunocytochemistry: 2-10ug/ml

Western Blot (WB) of anti-CACYBP antibody

Western Blot of Recombinant CacyBP using MBS602942.
Mouse Anti-CACYBP Monoclonal Antibody – Cat# MBS602942

Testing Data of anti-CACYBP antibody

Whole cell lysate from human HEK293 (H, 25ug) , mouse NIH3T3 (M, 25ug) and rat F2408 (R, 25ug) cells. Predicted molecular weight: 26kD.
Mouse Anti-CACYBP Monoclonal Antibody, Testing Data – Cat# MBS602942

Testing Data of anti-CACYBP antibody

HeLa cells were fixed in 2% paraformaldehyde/PBS and then permeabilized in 90% methanol. Cells were stained with MBS602942 (shaded) or isotype control (unshaded) followed by Alexa Fluor® 488- conjugated goat anti-mouse IgG.
Mouse Anti-CACYBP Monoclonal Antibody, Testing Data – Cat# MBS602942

Testing Data of anti-CACYBP antibody

HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with MBS602942.
Mouse Anti-CACYBP Monoclonal Antibody, Testing Data – Cat# MBS602942

Other Notes

Small volumes of anti-CACYBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CACYBP purchase

MBS602942 is an antibody targeting CACYBP. Also known as Calcyclin Binding Protein (CACYBP, GIG5, MGC87971, PNAS-107, RP1-102G20.6, SIP, S100A6BP). Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CACYBP. It may not necessarily be applicable to this product.

NCBI GI #
3063653
NCBI GeneID
27101
UniProt Primary Accession #
Q5R371
UniProt Related Accession #
Q5R370; Q5R371; Q6NVY0; Q9HB71
NCBI Official Full Name
calcyclin binding protein
NCBI Official Synonym Full Names
calcyclin binding protein
NCBI Official Symbol
CACYBP
NCBI Official Synonym Symbols
SIP; GIG5; MGC87971; PNAS-107; S100A6BP; RP1-102G20.6
UniProt Protein Name
Calcyclin binding protein
Protein Family
Calcyclin-binding protein
UniProt Gene Name
CACYBP
UniProt Entry Name
Q5R371_HUMAN
NCBI Protein Information
calcyclin-binding protein; hCacyBP; OTTHUMP00000032884; OTTHUMP00000032885; OTTHUMP00000201857; S100A6-binding protein; Siah-interacting protein (SIP); growth-inhibiting gene 5 protein

NCBI Summary for CACYBP

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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UniProt Comments for CACYBP

CACYBP: a nuclear/cytoplasmic protein involved in calcium-dependent ubiquitination and proteosomal degradation of target proteins. A possible molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). Interacts with proteins of the S100 family at physiological calcium concentrations. Component of some large E3 complexes and interacts directly with SIAH1, SIAH2 and SKP1A. Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated. Two alternatively spliced isoforms have been described.

Protein type: Ubiquitin conjugating system; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q24-q25

Cellular Component: nucleoplasm; neuron projection; nuclear envelope lumen; cytoplasm; beta-catenin destruction complex

Molecular Function: protein binding; protein homodimerization activity

Biological Process: cardiac muscle cell differentiation; positive regulation of DNA replication; aging
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Research Articles on CACYBP

1. Poor cellular differentiation, lymph node invasion, and clinicopathological staging in breast cancer were associated with CacyBP/SIP expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CACYBP antibody

 Reference Product  PubMed Publications
 S100A6 antibody  >20 publications with CACYBP and S100A6
 SKP1 antibody  >15 publications with CACYBP and SKP1
 S100B antibody  >6 publications with CACYBP and S100B
 SIAH1 antibody  >4 publications with CACYBP and SIAH1
 S100P antibody  >4 publications with CACYBP and S100P
 S100A1 antibody  >3 publications with CACYBP and S100A1
 S100A12 antibody  >2 publications with CACYBP and S100A12

Pathways associated with anti-CACYBP antibody

 Products by Pathway  Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram

Diseases associated with anti-CACYBP antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >19 publications with CACYBP and Neoplasms
 Stomach Neoplasms Antibodies  >7 publications with CACYBP and Stomach Neoplasms
 Carcinoma Antibodies  >6 publications with CACYBP and Carcinoma
 Adenocarcinoma Antibodies  >3 publications with CACYBP and Adenocarcinoma
 Kidney Diseases Antibodies  >3 publications with CACYBP and Kidney Diseases
 Neoplasm Metastasis Antibodies  >3 publications with CACYBP and Neoplasm Metastasis
 Female Urogenital Diseases Antibodies  >2 publications with CACYBP and Female Urogenital Diseases
 Breast Neoplasms Antibodies  >2 publications with CACYBP and Breast Neoplasms
 Kidney Neoplasms Antibodies  >2 publications with CACYBP and Kidney Neoplasms
 Acute Lung Injury Antibodies  >1 publications with CACYBP and Acute Lung Injury

Organs/Tissues associated with anti-CACYBP antibody

 Organ/Tissue Name  Pubmed Publications
 Stomach Antibodies  >8 publications with CACYBP and Stomach
 Brain Antibodies  >8 publications with CACYBP and Brain
 Kidney Antibodies  >4 publications with CACYBP and Kidney
 Ascites Antibodies  >4 publications with CACYBP and Ascites
 Blood Antibodies  >3 publications with CACYBP and Blood
 Nerve Antibodies  >3 publications with CACYBP and Nerve
 Muscle Antibodies  >3 publications with CACYBP and Muscle
 Uterus Antibodies  >2 publications with CACYBP and Uterus
 Liver Antibodies  >2 publications with CACYBP and Liver
 Placenta Antibodies  >2 publications with CACYBP and Placenta
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