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Exostosin-Like 1 (EXTL1) Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS602976

Exostosin-like 1 (EXTL1) is a type II Golgi membrane protein and a glycosyl transferase that is required for the biosynthesis of heparan sulfate. The amino acid sequence of mouse EXTL1 is 92%, 76%, 75% and 74% identical to that of rat, chimpanzee, human and… More details

$970 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Exostosin-Like 1 (EXTL1), Monoclonal Antibody
Full Product Name
Exostosin-Like 1 (EXTL1)
Product Gene Name
Product Synonym Names
Anti -Exostosin-Like 1 (EXTL1)
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
7H119
Host
Rat
Species Reactivity
Mouse
Form/Format
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 1ml sterile, ddH2O or sterile 40-50% glycerol.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes mouse Exostosin-Like 1.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
74,697 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (26348271..26362955). Location: 1p36.1
OMIM
601738
3D Structure
ModBase 3D Structure for Q92935
Immunogen
NS0-derived recombinant mouse EXTL1 (aa30-669) Accession # NP_062524
Applications Tested/Suitable for anti-EXTL1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-EXTL1 antibody
Suitable for use in Western Blot, Immunoprecipitation and ELISA.
Dilution: Western Blot: 1-2ug/ml
Immunoprecipitation: 25ug/ml
ELISA: 0.5-1ug/ml

Other Notes

Small volumes of anti-EXTL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EXTL1 purchase

MBS602976 is an antibody targeting EXTL1. Also known as Exostosin-Like 1 (EXTL1). Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for EXTL1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
exostosin-like 1
NCBI Official Synonym Full Names
exostoses (multiple)-like 1
NCBI Official Symbol
EXTL1
NCBI Official Synonym Symbols
EXTL; MGC70794
UniProt Protein Name
Exostosin-like 1
UniProt Synonym Protein Names
Exostosin-L; Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Multiple exostosis-like protein
Protein Family
UniProt Gene Name
EXTL1
UniProt Synonym Gene Names
EXTL
UniProt Entry Name
EXTL1_HUMAN
NCBI Protein Information
exostosin-like 1; exostosin-L; OTTHUMP00000008700; multiple exostosis-like protein; alpha-N-acetylglucosaminyltransferase II; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N- acetylglucosaminyltransferase; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase

NCBI Summary for EXTL1

This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin. [provided by RefSeq]
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UniProt Comments for EXTL1

EXTL1: Probable glycosyltransferase. Belongs to the glycosyltransferase 47 family.

Protein type: Transferase; EC 2.4.1.224; Membrane protein, integral; Glycan Metabolism - heparan sulfate biosynthesis

Chromosomal Location of Human Ortholog: 1p36.1

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

Biological Process: glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process; protein amino acid glycosylation; skeletal development
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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