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Bone Morphogenic Protein 6 (BMP6) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS602979

Bone Morphogenetic Proteins (BMP) are members of the TGF beta superfamily of cytokines that affect bone and cartilage formation. Similar to other TGF beta family proteins, BMPs are highly conserved across animal species. BMPs are involved in embryogenesis and… More details

$970 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Bone Morphogenic Protein 6 (BMP6), Monoclonal Antibody
Full Product Name
Bone Morphogenic Protein 6 (BMP6, vgr-1, Vegetal Related, DVR-6, Decapentaplegic Vegetal Related)
Product Gene Name
anti-BMP6 antibody
Product Synonym Names
Anti -Bone Morphogenic Protein 6 (BMP6, vgr-1, Vegetal Related, DVR-6, Decapentaplegic Vegetal Related)
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
8J349
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 5% trehalose.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human Bone Morphogenic Protein 6. Shows <5% crossreactivity with recombinant human BMP5 and BMP7 and no crossreactivity with recombinant human BMP2 and BMP4 under reducing conditions.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
57,226 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (7727011..7881961). Location: 6p24-p23
OMIM
112266
3D Structure
ModBase 3D Structure for P22004
Immunogen
Recombinant full length human Bone Morphogenic Protein 6 expressed in CHO cells. Cellular Localization: Secreted

Product Categories/Family for anti-BMP6 antibody

Antibodies; Abs to Growth Factors; Cytokines
Applications Tested/Suitable for anti-BMP6 antibody
ELISA (EL/EIA), Western Blot (WB), Neutralization
Application Notes for anti-BMP6 antibody
Suitable for use in ELISA, Neutralization and Western Blot.
Dilution: ELISA: 0.5-1.0 ug/ml. The detecton limit for recombinant human BMP-6 is ~6.2 ng/well.
Western Blot: 1-20ug/ml. The detection limit for recombinant human BMP6 is ~ 20ng/lane under non-reducing conditions.
Neutralization: 0.5-2ug/ml

Other Notes

Small volumes of anti-BMP6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMP6 purchase

MBS602979 is an antibody targeting BMP6. Also known as Bone Morphogenic Protein 6 (BMP6, vgr-1, Vegetal Related, DVR-6, Decapentaplegic Vegetal Related). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for BMP6. It may not necessarily be applicable to this product.

NCBI GI #
4502425
NCBI GeneID
654
NCBI Accession #
NP_001709.1
UniProt Primary Accession #
P22004
UniProt Secondary Accession #
Q5TCP3
UniProt Related Accession #
P22004; Q4JCQ2; Q4VBA3
GenBank Nucleotide #
NM_001718.4
NCBI Official Full Name
bone morphogenetic protein 6 preproprotein
NCBI Official Synonym Full Names
bone morphogenetic protein 6
NCBI Official Symbol
BMP6
NCBI Official Synonym Symbols
VGR; VGR1
UniProt Protein Name
Bone morphogenetic protein 6
UniProt Synonym Protein Names
VG-1-related protein
Protein Family
Bone morphogenetic protein
UniProt Gene Name
BMP6
UniProt Synonym Gene Names
VGR
UniProt Entry Name
BMP6_HUMAN
NCBI Protein Information
bone morphogenetic protein 6; BMP-6; VGR-1; VG-1-R; OTTHUMP00000016006; VG-1-related protein; Vg1-related sequence; vegetal-related (TGFB related) cytokine; vegetal related growth factor (TGFB-related)

NCBI Summary for BMP6

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq]
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UniProt Comments for BMP6

BMP6: Induces cartilage and bone formation. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p24-p23

Cellular Component: extracellular space; cytoplasm

Molecular Function: growth factor activity; protein heterodimerization activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: cellular iron ion homeostasis; response to glucocorticoid stimulus; regulation of apoptosis; BMP signaling pathway; response to magnesium ion; positive regulation of endothelial cell differentiation; positive regulation of aldosterone biosynthetic process; male genitalia development; kidney development; inflammatory response; response to iron ion; skeletal development; endochondral ossification; response to retinoic acid; positive regulation of bone mineralization; osteoblast differentiation; positive regulation of osteoblast differentiation; positive regulation of chondrocyte differentiation; positive regulation of protein secretion; eye development; cartilage development; regulation of MAPKKK cascade; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; response to activity; positive regulation of neuron differentiation; positive regulation of epithelial cell proliferation; growth
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Research Articles on BMP6

1. a novel role of BMP-6/HO-1 cascade to relieve breast cancer metastasis by regulating the secretion of growth factors in tumor microenvironment.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BMP6 antibody

 Reference Product  PubMed Publications
 BMPR2 antibody  >40 publications with BMP6 and BMPR2
 BMPR1A antibody  >20 publications with BMP6 and BMPR1A
 SMAD5 antibody  >19 publications with BMP6 and SMAD5
 BMPR1B antibody  >10 publications with BMP6 and BMPR1B
 ACVR2A antibody  >4 publications with BMP6 and ACVR2A
 SOSTDC1 antibody  >1 publications with BMP6 and SOSTDC1
 BMPER antibody  >1 publications with BMP6 and BMPER

Pathways associated with anti-BMP6 antibody

 Products by Pathway  Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram

Diseases associated with anti-BMP6 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >61 publications with BMP6 and Neoplasms
 Metabolic Diseases Antibodies  >26 publications with BMP6 and Metabolic Diseases
 Iron Metabolism Disorders Antibodies  >18 publications with BMP6 and Iron Metabolism Disorders
 Carcinoma Antibodies  >17 publications with BMP6 and Carcinoma
 Prostatic Neoplasms Antibodies  >16 publications with BMP6 and Prostatic Neoplasms
 Inflammation Antibodies  >15 publications with BMP6 and Inflammation
 Hemochromatosis Antibodies  >15 publications with BMP6 and Hemochromatosis
 Skin Diseases Antibodies  >13 publications with BMP6 and Skin Diseases
 Cardiovascular Diseases Antibodies  >13 publications with BMP6 and Cardiovascular Diseases
 Anemia Antibodies  >12 publications with BMP6 and Anemia

Organs/Tissues associated with anti-BMP6 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >50 publications with BMP6 and Blood
 Connective Tissue Antibodies  >32 publications with BMP6 and Connective Tissue
 Embryonic Tissue Antibodies  >29 publications with BMP6 and Embryonic Tissue
 Brain Antibodies  >28 publications with BMP6 and Brain
 Ovary Antibodies  >22 publications with BMP6 and Ovary
 Vascular Antibodies  >20 publications with BMP6 and Vascular
 Prostate Antibodies  >19 publications with BMP6 and Prostate
 Kidney Antibodies  >11 publications with BMP6 and Kidney
 Parathyroid Antibodies  >10 publications with BMP6 and Parathyroid
 Lung Antibodies  >9 publications with BMP6 and Lung
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