Mouse Anti-CNOT6 Monoclonal Antibody – Cat# MBS602993

CCR4-Not Transcription Complex, Subunit 6 (CNOT6) Antibody – Mouse Monoclonal

Name: CNOT6 Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS602993
Price: 850 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS602993

MBS602993 is an antibody targeting CNOT6. Also known as CCR4-Not Transcription Complex, Subunit 6 (CNOT6, Carbon Catabolite Repressor Protein 4 Homolog, CCR4 Carbon Catabolite Repression 4-Like, Cytoplasmic Deadenylase, KIAA1194). Host: Mouse. The CCR4-Not… More details

$850 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CCR4-Not Transcription Complex, Subunit 6 (CNOT6), Monoclonal Antibody

Full Product Name

CCR4-Not Transcription Complex, Subunit 6 (CNOT6, Carbon Catabolite Repressor Protein 4 Homolog, CCR4 Carbon Catabolite Repression 4-Like, Cytoplasmic Deadenylase, KIAA1194)

Product Gene Name

anti-CNOT6 antibody

Product Synonym Names

Anti -CCR4-Not Transcription Complex, Subunit 6 (CNOT6, Carbon Catabolite Repressor Protein 4 Homolog, CCR4 Carbon Catabolite Repression 4-Like, Cytoplasmic Deadenylase, KIAA1194)

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

8C61

Host

Mouse

Form/Format

Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein G affinity chromatography.

Specificity

Recognizes human CCR4-Not Transcription Complex, Subunit 6.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

63,307 Da

Chromosome Location

Chromosome: 5; NC_000005.9 (179921417..180005353). Location: 5q35.3

OMIM

608951

3D Structure

ModBase 3D Structure for Q9ULM6

Immunogen

Partial sequence of recombinant full-length protein to human CCR4-Not Transcription Complex, Subunit 6

Product Categories/Family for anti-CNOT6 antibody

Antibodies; Abs to Transcription Factors

Applications Tested/Suitable for anti-CNOT6 antibody

ELISA (EL/EIA)

Application Notes for anti-CNOT6 antibody

Suitable for use in ELISA.

Other Notes

Small volumes of anti-CNOT6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CNOT6. It may not necessarily be applicable to this product.

NCBI GI #

28872863

NCBI GeneID

57472

NCBI Accession #

NP_056270.2

UniProt Primary Accession #

Q9ULM6

UniProt Secondary Accession #

A7MD46; D3DWR0

UniProt Related Accession #

Q8TAJ0; Q9ULM6

GenBank Nucleotide #

NM_015455.3

NCBI Official Full Name

CCR4-NOT transcription complex subunit 6

NCBI Official Synonym Full Names

CCR4-NOT transcription complex, subunit 6

NCBI Official Symbol

CNOT6

NCBI Official Synonym Symbols

CCR4; KIAA1194

UniProt Protein Name

CCR4-NOT transcription complex subunit 6

UniProt Synonym Protein Names

CCR4 carbon catabolite repression 4-like; Carbon catabolite repressor protein 4 homolog; Cytoplasmic deadenylase

Protein Family

CCR4-NOT transcription complex

UniProt Gene Name

CNOT6

UniProt Synonym Gene Names

CCR4; KIAA1194

UniProt Entry Name

CNOT6_HUMAN

NCBI Protein Information

CCR4-NOT transcription complex subunit 6; OTTHUMP00000161544; cytoplasmic deadenylase; carbon catabolite repression 4 protein; carbon catabolite repressor protein 4 homolog

NCBI Summary for CNOT6

The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substates. [provided by RefSeq]

UniProt Comments for CNOT6

CNOT6: Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general transcription regulation complex. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Belongs to the CCR4/nocturin family.

Protein type: Hydrolase; EC 3.1.13.4

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: membrane; cytosol; nucleus; CCR4-NOT complex

Molecular Function: protein binding; poly(A)-specific ribonuclease activity; exoribonuclease activity; RNA binding; metal ion binding

Biological Process: regulation of translation; poly(A) tail shortening; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of cell proliferation; gene expression; miRNA-mediated gene silencing; mRNA catabolic process, deadenylation-dependent decay

Research Articles on CNOT6

1. Results identified CNOT6/CNOT6L as a key regulator of insulin-like growth factor-binding protein 5, which mediates cell cycle arrest and senescence via a p53-dependent pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CNOT6 antibody

Reference Product	PubMed Publications
CNOT7 antibody	>2 publications with CNOT6 and CNOT7
CNOT8 antibody	>1 publications with CNOT6 and CNOT8

Pathways associated with anti-CNOT6 antibody

Products by Pathway	Pathway Diagram
Deadenylation Of MRNA Pathway antibodies	Deadenylation Of MRNA Pathway Diagram
Deadenylation-dependent MRNA Decay Pathway antibodies	Deadenylation-dependent MRNA Decay Pathway Diagram
Metabolism Of RNA Pathway antibodies	Metabolism Of RNA Pathway Diagram
Metabolism Of MRNA Pathway antibodies	Metabolism Of MRNA Pathway Diagram
RNA Degradation Pathway antibodies	RNA Degradation Pathway Diagram
RNA Degradation Pathway antibodies	RNA Degradation Pathway Diagram

Organs/Tissues associated with anti-CNOT6 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>1 publications with CNOT6 and Brain