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KLRG1 Antibody – Hamster Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS603175

Killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA or 2F1-Ag) is a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
KLRG1, Monoclonal Antibody
Full Product Name
KLRG1 (Killer Cell Lectin-like Receptor G1, MAFA, 2F1-Ag) (Biotin)
Product Gene Name
Product Synonym Names
Anti -KLRG1 (Killer Cell Lectin-like Receptor G1, MAFA, 2F1-Ag) (Biotin)
Clonality
Monoclonal
Isotype
IgG
Clone Number
5K32
Host
Hamster
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, 0.1% sodium azide. Conjugated to Biotin.
Purity/Purification
Purified
Purified
Specificity
Reacts with mouse killer cell lectin-like receptor G1 (KLRG1, Mr 30-38kD).
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20 degree C or colder. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
21,831 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (9142221..9163343). Location: 12p13.31
OMIM
604874
3D Structure
ModBase 3D Structure for Q96E93
Immunogen
Activated NK (A-LAK) cells from B6 (H-2b) mice

Product Categories/Family for anti-KLRG1 antibody

Applications Tested/Suitable for anti-KLRG1 antibody
Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
Application Notes for anti-KLRG1 antibody
Flow cytometry 1, 5, , Immunoprecipitation1, 5
Dilution: Flow Cytometry: 1ug/10e6 cells

Other Notes

Small volumes of anti-KLRG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KLRG1 purchase

MBS603175 is an antibody targeting KLRG1. Also known as KLRG1 (Killer Cell Lectin-like Receptor G1, MAFA, 2F1-Ag) (Biotin). Reactive in Mouse. Host: Hamster.

Additional Details

NCBI/Uniprot data below describe general gene information for KLRG1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
killer cell lectin-like receptor subfamily G member 1
NCBI Official Synonym Full Names
killer cell lectin-like receptor subfamily G, member 1
NCBI Official Symbol
KLRG1
NCBI Official Synonym Symbols
2F1; MAFA; MAFA-L; CLEC15A; MAFA-2F1; MGC13600; MAFA-LIKE
UniProt Protein Name
Killer cell lectin-like receptor subfamily G member 1
UniProt Synonym Protein Names
C-type lectin domain family 15 member A; ITIM-containing receptor MAFA-L; MAFA-like receptor; Mast cell function-associated antigen
UniProt Gene Name
KLRG1
UniProt Synonym Gene Names
CLEC15A; MAFA; MAFAL
UniProt Entry Name
KLRG1_HUMAN
NCBI Protein Information
killer cell lectin-like receptor subfamily G member 1; MAFA-like receptor; OTTHUMP00000238502; OTTHUMP00000238503; ITIM-containing receptor MAFA-L; C-type lectin domain family 15 member A; C-type lectin domain family 15, member A; mast cell function-associated antigen (ITIM-containing)

NCBI Summary for KLRG1

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined. [provided by RefSeq]
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UniProt Comments for KLRG1

KLRG1: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: integral to membrane; plasma membrane

Molecular Function: receptor activity; carbohydrate binding

Biological Process: regulation of immune response; cell surface receptor linked signal transduction; cellular defense response; innate immune response; inflammatory response
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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