Chorionic Gonadotropin C2 (PLA2G4A) Antibody – Mouse Monoclonal

Function: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response

By similarity.

Catalytic activity: Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation: Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca2+

By similarity.

Subunit structure: Interacts with KAT5

By similarity.

Subcellular location: Cytoplasm

By similarity. Cytoplasmic vesicle

By similarity. Note: Translocates to membrane vesicles in a calcium-dependent fashion

By similarity.

Tissue specificity: Detected in granulosa cells after stimulation with chorionic gonadotropin (at protein level). Ref.1

Developmental stage: Highly expressed in granulosa cells of ovulatory follicles. Detected at low levels in granulosa cells during the rest of the estrous cycle.

Domain: The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca2+

By similarity.

Post-translational modification: Activated by phosphorylation at both Ser-505 and Ser-727

By similarity.

Sequence similarities: Contains 1 C2 domain.Contains 1 PLA2c domain.