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LRP, MVP (MVP) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS603552

MBS603552 is an antibody targeting MVP. Also known as LRP, MVP (Major Vault Protein, Lung-resistance Related Protein). Reactive in Human. Host: Mouse. More details

$805 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LRP, MVP, Monoclonal Antibody
Full Product Name
LRP, MVP (Major Vault Protein, Lung-resistance Related Protein)
Product Gene Name
Product Synonym Names
Anti -LRP, MVP (Major Vault Protein, Lung-resistance Related Protein)
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
6D537
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid. Antibody in serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.
Purity/Purification
Supernatant
Supernatant
Specificity
Recognizes an internal epitope (P110) of human MVP/LRP, which is overexpressed in various human non-P-glycoprotein MDR tumor cell lines.
Preparation and Storage
-20 degree C
Molecular Weight
99,327 Da
OMIM
605088
3D Structure
ModBase 3D Structure for Q14764
Immunogen
Human MVP/LRP (major vault protein / lung resistance protein).
Positive Control
Cell lines: Appropriate drug-sensitive parental cell lines and their multdrug resistant derivatives prepared by the same methods as the test specimens should be used as control materials.
Tissue: Human colon, kidney, bronchus or adrenal are recommended.
Applications Tested/Suitable for anti-MVP antibody
Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)
Application Notes for anti-MVP antibody
Flow Cytometry (cell permeabilization required), Immunocytochemistry (cytospin preparations), Immunohistochemistry (frozen sections, paraffin sections)., Recommended starting dilution is 1:20. Optimal conditions should be determined individually for each application.

Testing Data of anti-MVP antibody

Liver cells stained with MBS603552.
Mouse Anti-MVP Monoclonal Antibody – Cat# MBS603552

Other Notes

Small volumes of anti-MVP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MVP. It may not necessarily be applicable to this product.

NCBI GI #
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
NCBI Official Full Name
lrp
UniProt Protein Name
Major vault protein
UniProt Synonym Protein Names
Lung resistance-related protein
UniProt Gene Name
MVP
UniProt Synonym Gene Names
LRP; MVP
UniProt Entry Name
MVP_HUMAN

UniProt Comments for MVP

MVP: Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoskeleton; membrane; perinuclear region of cytoplasm; cytoplasm; nuclear pore; nucleus; ribonucleoprotein complex

Molecular Function: protein binding; protein phosphatase binding; protein kinase binding

Biological Process: cell proliferation; protein transport; mRNA transport; negative regulation of protein amino acid autophosphorylation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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