PRMT2 Antibody – Mouse Monoclonal

PRMT2: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation. Belongs to the protein arginine N-methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus; Nuclear receptor co-regulator; Methyltransferase; Methyltransferase, protein arginine; EC 2.1.1.125

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: nucleoplasm; Rb-E2F complex; cytoplasm; nucleolus; nucleus; cytosol

Molecular Function: histone methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; protein-arginine N-methyltransferase activity; peroxisome proliferator activated receptor binding; protein homodimerization activity; retinoic acid receptor binding; transcription coactivator activity; histone-arginine N-methyltransferase activity; signal transducer activity; protein binding; androgen receptor binding; estrogen receptor binding; thyroid hormone receptor binding; progesterone receptor binding

Biological Process: histone methylation; developmental cell growth; protein amino acid methylation; inhibition of NF-kappaB transcription factor; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; negative regulation of transcription, DNA-dependent; signal transduction