• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

MCAM Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS604218

Chicken MCAM, a member of the immunoglobulin superfamily of cell surface receptors, consists of the V-V-C2-C2-C2 Ig domains. It is a single chain glycoprotein with three mRNA splice variants. One has a short cytoplasmic tail, another has a long tail, and the… More details

$655 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MCAM, Monoclonal Antibody
Full Product Name
MCAM (Melanoma Cell Adhesion Molecule) (PE)
Product Gene Name
anti-MCAM antibody
Product Synonym Names
Anti -MCAM (Melanoma Cell Adhesion Molecule) (PE)
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
5K96
Host
Mouse
Species Reactivity
Chicken
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide and a stabilizing agent. Labeled with PE.
Purity/Purification
Purified
Concentration
0.1 mg/mL (lot specific)
Specificity
Recognizes chicken MCAM, Mr 98kD (protein core ~84kD).
Preparation and Storage
Store product a 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as a undiluted liquid. Dilute required amount only prior to inmediate use. Further dilutions can be made in assay buffer.

Caution: PE conjugates are sensitive to light . For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Chromosome Location
Chromosome: 11; NC_000011.9 (119179234..119187840, complement). Location: 11q23.3
OMIM
155735
3D Structure
ModBase 3D Structure for P43121
Immunogen
Pooled Ed15 and Ed16 thymocytes from H.B15, H.B19 and H.B21 chicken embryos

Product Categories/Family for anti-MCAM antibody

Antibodies; Abs to Cancer Markers
Applications Tested/Suitable for anti-MCAM antibody
Suitable for use in Flow Cytometry. Other applications not tested.
Application Notes for anti-MCAM antibody
Flow Cytometry: 0.2 ug/10e6 cells

Optimal dilutions to be determined by the researcher.

Flow Cytometry (FC/FACS) of anti-MCAM antibody

Flow Cytometry of chicken thymocytes using MBS604218.
Mouse Anti-MCAM Monoclonal Antibody – Cat# MBS604218

Other Notes

Small volumes of anti-MCAM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCAM purchase

MBS604218 is an antibody targeting MCAM. Also known as MCAM (Melanoma Cell Adhesion Molecule) (PE). Reactive in Chicken. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MCAM. It may not necessarily be applicable to this product.

NCBI GI #
33989399
NCBI GeneID
4162
UniProt Primary Accession #
P43121
UniProt Secondary Accession #
O95812; Q59E86; Q6PHR3; Q6ZTR2
UniProt Related Accession #
P43121
NCBI Official Full Name
Melanoma cell adhesion molecule
NCBI Official Synonym Full Names
melanoma cell adhesion molecule
NCBI Official Symbol
MCAM
NCBI Official Synonym Symbols
CD146; MUC18
UniProt Protein Name
Cell surface glycoprotein MUC18
UniProt Synonym Protein Names
Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen
Protein Family
Cell surface glycoprotein
UniProt Gene Name
MCAM
UniProt Synonym Gene Names
MUC18
UniProt Entry Name
MUC18_HUMAN
NCBI Protein Information
cell surface glycoprotein MUC18; Gicerin; OTTHUMP00000232151; melanoma adhesion molecule; cell surface glycoprotein P1H12; melanoma-associated antigen A32; melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen

UniProt Comments for MCAM

MCAM: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: extracellular space; focal adhesion; integral to membrane; plasma membrane; nucleus; external side of plasma membrane

Biological Process: anatomical structure morphogenesis; glomerular filtration; angiogenesis; cell adhesion; positive regulation of cell migration
Show more

Research Articles on MCAM

1. MUC18 is involved in cell signaling regulating the expression of Id-1 and ATF-3, thus contributing to melanoma metastasis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MCAM antibody

 Reference Product  PubMed Publications
 FYN antibody  >2 publications with MCAM and FYN

Diseases associated with anti-MCAM antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >131 publications with MCAM and Neoplasms
 Skin Diseases Antibodies  >27 publications with MCAM and Skin Diseases
 Skin Neoplasms Antibodies  >22 publications with MCAM and Skin Neoplasms
 Adenocarcinoma Antibodies  >16 publications with MCAM and Adenocarcinoma
 Prostatic Neoplasms Antibodies  >14 publications with MCAM and Prostatic Neoplasms
 Melanoma, Experimental Antibodies  >14 publications with MCAM and Melanoma, Experimental
 Inflammation Antibodies  >13 publications with MCAM and Inflammation
 Lung Diseases Antibodies  >13 publications with MCAM and Lung Diseases
 Lung Neoplasms Antibodies  >11 publications with MCAM and Lung Neoplasms
 Breast Neoplasms Antibodies  >11 publications with MCAM and Breast Neoplasms

Organs/Tissues associated with anti-MCAM antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >61 publications with MCAM and Vascular
 Blood Antibodies  >59 publications with MCAM and Blood
 Skin Antibodies  >32 publications with MCAM and Skin
 Embryonic Tissue Antibodies  >27 publications with MCAM and Embryonic Tissue
 Bone Antibodies  >23 publications with MCAM and Bone
 Lung Antibodies  >22 publications with MCAM and Lung
 Muscle Antibodies  >21 publications with MCAM and Muscle
 Bone Marrow Antibodies  >20 publications with MCAM and Bone Marrow
 Prostate Antibodies  >18 publications with MCAM and Prostate
 Placenta Antibodies  >15 publications with MCAM and Placenta
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000