VAMP 1,2 (VAMP1) Antibody – Mouse Monoclonal

Vesicle-associated membrane protein (VAMP), also known as synaptobrevin, is an 18kD integral membrane protein localized to the cytoplasmic surface of synaptic vesicle (2). VAMP consists of a proline-rich amino-terminal region, a highly conserved hydrophilic domain, followed by a transmembrane anchor and a carboxyl-terminal tail (3). Two VAMP homologs, VAMP1 and VAMP2, are differentially expressed in the nervous system (3). VAMP1 expression is localized to neurons involved in modulating overlapping patterns, whereas VAMP2 is found in neurons associated with autonomic, sensory and integrative functions. In non-neuronal tissues, VAMP1 is restricted to pancreas and kidney tubular cells, whereas VAMP2 is predominantly expressed in Langerhans islets and glomerular cells (4). Evidences for VAMP's involvement in vesicular transport and neurotransmission include the requirement of its yeast homologs, SNC 1 and 2, in targeting and fusion of Golgi- derived vesicles with the plasma membrane (5). VAMP is also the target of clostridial neurotoxins that block neurotransmitter release from presynaptic terminals (6). VAMP is a component of a 20S complex implicated in vesicle docking and fusion. The formation of 20S complex involves the interaction of VAMP with syntaxin through an ATP-dependent reaction modulated by synaptotagmin, SNAP-25, alpha-SNAP, and NSF (7).

Small volumes of anti-VAMP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS604808 is an antibody targeting VAMP1. Also known as VAMP 1,2 (Vesicle-Associated Membrane Protein, Synaptobrevin). Reactive in Bovine, Hamster, Human, Mouse, Porcine, Rat, Xenopus. Host: Mouse.