AMP Activated Protein Kinase Alpha1/2 (ADRA1B) Antibody – Mouse Monoclonal

ADRA1B: a G protein-coupled catecholamine receptor that activates mitogenic responses and regulates growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. Can induce neoplastic transformation when transfected into cell lines. Can regulate the phosphorylation status of the STAT3 pathway. Mediates blood pressure and aorta contractile responses induced by alpha-1 agonists. Activates a phosphatidylinositol second messenger system.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: nuclear membrane; membrane; T-tubule; integral to membrane; plasma membrane; cytosol; nucleus

Molecular Function: G-protein coupled receptor activity; signal transducer activity; adrenoceptor activity; protein heterodimerization activity; alpha1-adrenergic receptor activity

Biological Process: adult heart development; vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure; regulation of muscle contraction; positive regulation of the force of heart contraction by epinephrine-norepinephrine; response to amphetamine; response to hormone stimulus; response to morphine; locomotory behavior; signal transduction; glucose homeostasis; positive regulation of glycogen catabolic process; organ growth; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of MAPKKK cascade; negative regulation of Rho protein signal transduction; behavioral response to cocaine; response to steroid hormone stimulus; regulation of vasoconstriction; visual learning; blood vessel remodeling; cell growth; positive regulation of heart rate by epinephrine-norepinephrine; negative regulation of glycogen catabolic process