Mouse Anti-ASGR1 Monoclonal Antibody – Cat# MBS605210

FC: detection of ASGPR in HepG2 cells. Red, black and blue line represent the isotype control, cells only and HM3020F with a concentration of 10 ?g/ml, respectively.

Asialoglycoprotein RECEPTOR (ASGR1) Antibody – Mouse Monoclonal

Name: ASGR1 Antibody; Monoclonal; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS605210
Price: 1320 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS605210

The asialoglycoprotein (ASGP) receptor is a transmembrane hepatocellular surface carbohydrate binding glycoproteins lacking terminal sialic acid residues (asialoglycoproteins). Characterization of the ASGP receptor revealed its functional role in the binding,… More details

$1320 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ASIALOGLYCOPROTEIN RECEPTOR (ASGR1), Monoclonal Antibody

Full Product Name

ASIALOGLYCOPROTEIN RECEPTOR (ASGPR)

Product Gene Name

anti-ASGR1 antibody

Product Synonym Names

Asialoglycoprotein receptor 1, ASGPR 1, ASGP-R 1, Hepatic lectin 1, MHL-1

Clonality

Monoclonal

Isotype

IgG1

Clone Number

9G132

Host

Mouse

Form/Format

0.2 um filtered in PBS+0.1%, BSA + 0.02%, NaN3

Purity/Purification

Protein G

Concentration

100 ug/ml (lot specific)

Specificity

Recognizes a subunit-specific epitope on RHL-1 of rat ASGPR. Species crossreactivity: human.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Chromosome Location

Chromosome: 17; NC_000017.10 (7076750..7082883, complement). Location: 17p13.2

OMIM

108360

3D Structure

ModBase 3D Structure for P07306

Immunogen

Crude rat liver membrane extracts

Cross Reactivity

Human

Product Categories/Family for anti-ASGR1 antibody

Antibodies; Abs to Receptors

Applications Tested/Suitable for anti-ASGR1 antibody

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF)

Application Notes for anti-ASGR1 antibody

Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions.
The typical starting working dilution is 1:50.
WB: A non-reduced sample treatment and SDS-Page was used. The band size is 42 kDa (ref.4).
FC: aceton fixed tissue section were incubated Hybridoma culture supernatant.
IA: microtiter plates were coated with 100?l 20ug/ml for ELISA.
Positive control: Rat hepatocytes; Negative control: Rat kidney, pancreas, small intestine, colon

Other Notes

Small volumes of anti-ASGR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ASGR1 purchase

MBS605210 is an antibody targeting ASGR1. Also known as ASIALOGLYCOPROTEIN RECEPTOR (ASGPR). Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ASGR1. It may not necessarily be applicable to this product.

NCBI GI #

4502251

NCBI GeneID

432

NCBI Accession #

NP_001662.1

UniProt Primary Accession #

P07306

UniProt Related Accession #

P07306; Q6FGQ5

GenBank Nucleotide #

NM_001671.4

NCBI Official Full Name

asialoglycoprotein receptor 1 isoform a

NCBI Official Synonym Full Names

asialoglycoprotein receptor 1

NCBI Official Symbol

ASGR1

NCBI Official Synonym Symbols

HL-1; ASGPR; ASGPR1; CLEC4H1

UniProt Protein Name

Asialoglycoprotein receptor 1

UniProt Synonym Protein Names

C-type lectin domain family 4 member H1; Hepatic lectin H1

Protein Family

Asialoglycoprotein receptor

UniProt Gene Name

ASGR1

UniProt Synonym Gene Names

CLEC4H1

UniProt Entry Name

ASGR1_HUMAN

NCBI Protein Information

asialoglycoprotein receptor 1; hepatic lectin H1; OTTHUMP00000128354; C-type lectin domain family 4 member H1

NCBI Summary for ASGR1

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq]

UniProt Comments for ASGR1

ASGR1: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: integral to plasma membrane; extracellular region

Molecular Function: protein binding; protein homodimerization activity; metal ion binding; asialoglycoprotein receptor activity; carbohydrate binding

Biological Process: receptor-mediated endocytosis; cellular response to extracellular stimulus

Research Articles on ASGR1

1. Asialoglycoprotein receptor (ASGPR) interacted specifically and directly with the preS1 domain of HBV in vivo and in vitro.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ASGR1 antibody

Reference Product	PubMed Publications
ITGA1 antibody	>1 publications with ASGR1 and ITGA1

Diseases associated with anti-ASGR1 antibody

Disease Name	Pubmed Publications
Hepatitis Antibodies	>2 publications with ASGR1 and Hepatitis
Neoplasms Antibodies	>1 publications with ASGR1 and Neoplasms
Fibrosis Antibodies	>1 publications with ASGR1 and Fibrosis

Organs/Tissues associated with anti-ASGR1 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>2 publications with ASGR1 and Liver
Skin Antibodies	>1 publications with ASGR1 and Skin