Mouse Anti-TRPC5 Monoclonal Antibody – Cat# MBS605426

Western blot detection of human TrpC5 expression in human epidermoid carcinoma whole cell lysate.

TRPC5 Antibody – Mouse Monoclonal

Name: TRPC5 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS605426
Price: 700 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS605426

It has been demonstrated that TrpC1 and TrpC5 are subunits of a heteromeric neuronal channel in mammalian brain. TrpC5 is thought to form a receptor-activatd non-selective permeant cation channel. It is probably operated by a phosphatidylinositol second… More details

$700 / 0.05 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TrpC5, Monoclonal Antibody

Full Product Name

TrpC5 (Short transient receptor potential channel 5, Htrp-5, Htrp5, TRPC5, TRP5)

Product Gene Name

anti-TRPC5 antibody

Product Synonym Names

Anti -TrpC5 (Short transient receptor potential channel 5, Htrp-5, Htrp5, TRPC5, TRP5)

Clonality

Monoclonal

Isotype

IgG

Clone Number

9G456

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a lyophilized powder. Reconstitute in 100ul sterile water, 40-50% glycerol.

Purity/Purification

Ascites
Ascites

Specificity

Recognizes human TrpC5.

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20 degree C. Aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

111,412 Da

Chromosome Location

Chromosome: X; NC_000023.10 (111017542..111326004, complement). Location: Xq23

OMIM

300334

3D Structure

ModBase 3D Structure for Q9UL62

Immunogen

Partial recombinant human TrpC5 (aa534-604) with a GST tag.

Product Categories/Family for anti-TRPC5 antibody

Antibodies; Abs to Ion Channel

Applications Tested/Suitable for anti-TRPC5 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-TRPC5 antibody

Suitable for use in ELISA and Western Blot.

Other Notes

Small volumes of anti-TRPC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRPC5 purchase

MBS605426 is an antibody targeting TRPC5. Also known as TrpC5 (Short transient receptor potential channel 5, Htrp-5, Htrp5, TRPC5, TRP5). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TRPC5. It may not necessarily be applicable to this product.

NCBI GI #

6002474

NCBI GeneID

7224

UniProt Primary Accession #

Q9UL62

UniProt Secondary Accession #

O75233; Q5JXY8; Q9Y514; B2RP53

UniProt Related Accession #

Q59G51; Q9UL62

NCBI Official Full Name

transient receptor potential calcium channel 5

NCBI Official Synonym Full Names

transient receptor potential cation channel, subfamily C, member 5

NCBI Official Symbol

TRPC5

NCBI Official Synonym Symbols

TRP5

UniProt Protein Name

Short transient receptor potential channel 5

UniProt Synonym Protein Names

Transient receptor protein 5

Protein Family

Short transient receptor potential channel

UniProt Gene Name

TRPC5

UniProt Synonym Gene Names

TRP5

UniProt Entry Name

TRPC5_HUMAN

NCBI Protein Information

short transient receptor potential channel 5; TRP-5; hTRP5; OTTHUMP00000023863; transient receptor protein 5

NCBI Summary for TRPC5

This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq]

UniProt Comments for TRPC5

TRPC5: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq23

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; store-operated calcium channel activity; calcium channel activity

Biological Process: axon guidance; nervous system development; calcium ion transport; transmembrane transport

Research Articles on TRPC5

1. TRPC5 channel sensitivities to antioxidants and hydroxylated stilbenes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TRPC5 antibody

Reference Product	PubMed Publications
TRPC1 antibody	>97 publications with TRPC5 and TRPC1
TRPC4 antibody	>89 publications with TRPC5 and TRPC4

Pathways associated with anti-TRPC5 antibody

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Netrin-1 Signaling Pathway antibodies	Netrin-1 Signaling Pathway Diagram
Role Of Second Messengers In Netrin-1 Signaling Pathway antibodies	Role Of Second Messengers In Netrin-1 Signaling Pathway Diagram

Diseases associated with anti-TRPC5 antibody

Disease Name	Pubmed Publications
Hypertension Antibodies	>10 publications with TRPC5 and Hypertension
Acidosis Antibodies	>4 publications with TRPC5 and Acidosis

Organs/Tissues associated with anti-TRPC5 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>46 publications with TRPC5 and Brain
Placenta Antibodies	>2 publications with TRPC5 and Placenta