P53, Dimethylated Antibody – Mouse Monoclonal

The C terminus of p53 is rich in lysines, which are subjected to different modifications to regulate p53 activity. p53 tumor suppressor gene mutations are one of the most common genetic alterations in human tumors, including lymphomas. Altering or inactivating p53 by mutation or reaction with oncogenes or viruses may cause depletion of p53, or conversion of p53 from a tumor suppressor gene to a transforming oncogene. The nuclear protein p53 is associated with cell transformation and proliferation, with definitive possibilities as a marker in malignant lymphoma progression. p53's role in the multistep process leading to cancer is still being investigated, with an emphasis on its relation and control over additional tumor suppressors.

Small volumes of anti-p53, dimethylated antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS605651 is an antibody targeting p53, dimethylated. Also known as p53, dimethylated (Tumor Suppressor Protein, Oncogene Protein). Host: Mouse.