HESR1 (HEY1) Antibody – Mouse Monoclonal

This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

HEY1: Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Belongs to the HEY family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 8q21

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein dimerization activity; protein binding; transcription factor activity; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; positive regulation of osteoblast differentiation; Notch signaling pathway; negative regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; vasculogenesis; anterior/posterior axis specification; osteoblast development