• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Macrophage Inhibitory Cytokine-1 (GDF15) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS605694

Macrophage inhibitory cytokine-1 (MIC-1) is a member of the transforming growth factor-beta superfamily that regulates a wide variety of physiological processes involved in tissue differentiation and maintenance (1). MIC-1 is synthesized as a 62kD… More details

$580 / 0.05 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Macrophage inhibitory cytokine-1 (GDF15), Monoclonal Antibody
Full Product Name
Macrophage inhibitory cytokine-1 (MIC-1)
Product Gene Name
anti-GDF15 antibody
Product Synonym Names
Anti -Macrophage inhibitory cytokine-1 (MIC-1)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
9E99
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Concentration
2mg/ml (lot specific)
Specificity
Recognizes native human Macrophage inhibitory cytokine-1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Molecular Weight
34,140 Da
Chromosome Location
chromosome: 19; Location: 19p13.11
OMIM
605312
3D Structure
ModBase 3D Structure for Q99988
Immunogen
cDNA encoding aa30-194 from the N-terminal of human MIC-1 proprotein.

Product Categories/Family for anti-GDF15 antibody

Antibodies; Abs to Growth Factors; Cytokines
Applications Tested/Suitable for anti-GDF15 antibody
ELISA (EL/EIA), Flow Cytometry (FC/FACS)
Application Notes for anti-GDF15 antibody
Suitable for use in ELISA, Flow Cytometry and Immunoelectrophoresis.
Dilution: ELISA: 1:200-1:400
Flow Cytometry: 1.2ug/10e6 cells

Testing Data of anti-GDF15 antibody

FACS analysis of BOSC23 cells using MBS605694. BOSC23 cells were transiently transfected with an expression vector encoding either MIC-1 (red curve) or an irrelevant protein (control transfectant: black curve). Binding of MBS605694 was detected with a PE-conjugated secondary antibody. A positive signal was obtained only with MIC-1 transfected cells.
Mouse Anti-GDF15 Monoclonal Antibody – Cat# MBS605694

Testing Data of anti-GDF15 antibody

Capillary gel electrophoresis of MBS605694. Lane 1: molecular weight marker, Lane 2: MBS605694. Proteins were separated by CGE, Agilent 2100 Bioanalyzer. Internal control bands (240kD, 7kD, 4,5kD).
Mouse Anti-GDF15 Monoclonal Antibody, Testing Data – Cat# MBS605694

Other Notes

Small volumes of anti-GDF15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GDF15 purchase

MBS605694 is an antibody targeting GDF15. Also known as Macrophage inhibitory cytokine-1 (MIC-1). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for GDF15. It may not necessarily be applicable to this product.

NCBI GI #
2674085
NCBI GeneID
9518
UniProt Primary Accession #
Q99988
UniProt Secondary Accession #
O14629; P78360; Q9BWA0; Q9NRT0
UniProt Related Accession #
Q99988
NCBI Official Full Name
macrophage inhibitory cytokine-1
NCBI Official Synonym Full Names
growth differentiation factor 15
NCBI Official Symbol
GDF15
NCBI Official Synonym Symbols
PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; GDF15
UniProt Protein Name
Growth/differentiation factor 15
UniProt Synonym Protein Names
Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor
Protein Family
Growth/differentiation factor
UniProt Gene Name
GDF15
UniProt Synonym Gene Names
MIC1; PDF; PLAB; PTGFB
UniProt Entry Name
GDF15_HUMAN
NCBI Protein Information
growth/differentiation factor 15; NRG-1; PTGF-beta; placental TGF-beta; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; prostate differentiation factor; macrophage inhibitory cytokine 1; placental bone morphogenetic protein; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1

NCBI Summary for GDF15

Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM]
Show more

UniProt Comments for GDF15

GDF15: disulfide-linked. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: regulation of apoptosis; cell-cell signaling; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway; signal transduction; cell development
Show more

Research Articles on GDF15

1. Inhibition of c-Src activity resulted in the complete abolition of MIC-1-induced phosphorylation of the EGFR, ErbB2, and ErbB3, as well as invasiveness and matrix metalloproteinase-9 expression in SK-BR-3 cells.
2. GDF-15 is independently related to adverse events in non-ST-segment-elevation acute coronary syndrome both in the acute setting and for at least 6 months after clinical stabilization.
3. Baseline MIC-1 concentrations were increased, not decreased, in individuals before type 2 diabetes manifestation, but not independently associated with incident type 2 diabetes in multivariable analyses.
4. a progressive increase in secretory MIC-1 production correlated with the increase in the metastatic potential of PC-3 and LNPCa prostate cancer metastatic variants.
5. The integrated stress response-associated signals modulates intestinal tumor cell growth by NSAID-activated gene 1.
6. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
7. There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in oesophago-gastric cancer.
8. This study identifies GDF-15 as a strong and independent predictor of coronary heart disease (CHD) mortality across the broad spectrum of patients with stable and unstable CHD.
9. The prognostic information provided by GDF-15 in cardiovascular disease may inform patient management, e.g., by identifying patients with non-ST segment elevation acute coronary syndrome.
10. Data show that MIC-1 is a new diagnostic marker in the differential diagnosis of dyspnea.
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GDF15 antibody

 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram

Diseases associated with anti-GDF15 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >162 publications with GDF15 and Neoplasms
 Cardiovascular Diseases Antibodies  >60 publications with GDF15 and Cardiovascular Diseases
 Carcinoma Antibodies  >56 publications with GDF15 and Carcinoma
 Heart Diseases Antibodies  >46 publications with GDF15 and Heart Diseases
 Prostatic Neoplasms Antibodies  >38 publications with GDF15 and Prostatic Neoplasms
 Colorectal Neoplasms Antibodies  >34 publications with GDF15 and Colorectal Neoplasms
 Inflammation Antibodies  >34 publications with GDF15 and Inflammation
 Vascular Diseases Antibodies  >32 publications with GDF15 and Vascular Diseases
 Intestinal Diseases Antibodies  >28 publications with GDF15 and Intestinal Diseases
 Myocardial Ischemia Antibodies  >27 publications with GDF15 and Myocardial Ischemia

Organs/Tissues associated with anti-GDF15 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >117 publications with GDF15 and Blood
 Prostate Antibodies  >55 publications with GDF15 and Prostate
 Bone Antibodies  >54 publications with GDF15 and Bone
 Heart Antibodies  >49 publications with GDF15 and Heart
 Brain Antibodies  >38 publications with GDF15 and Brain
 Liver Antibodies  >27 publications with GDF15 and Liver
 Vascular Antibodies  >27 publications with GDF15 and Vascular
 Lung Antibodies  >22 publications with GDF15 and Lung
 Embryonic Tissue Antibodies  >15 publications with GDF15 and Embryonic Tissue
 Muscle Antibodies  >14 publications with GDF15 and Muscle
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000