• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Thimet Oligopeptidase (THOP1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS605765

A steady-state level of amyloid beta-peptide (Abeta) represents a balance between its biosynthesis from the amyloid precursor protein (APP) through the action of the beta and gamma-secretases and its catabolism by a variety of proteolytic enxymes. Thimet… More details

$775 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Thimet Oligopeptidase (THOP1), Monoclonal Antibody
Full Product Name
Thimet Oligopeptidase (TOP, Thimet Oligopeptidase 1, THOP1, EC 3.4.24.15, Endopeptidase 24.15, EP24.15, MP78, MEPD_HUMAN)
Product Gene Name
Product Synonym Names
Anti -Thimet Oligopeptidase (TOP, Thimet Oligopeptidase 1, THOP1, EC 3.4.24.15, Endopeptidase 24.15, EP24.15, MP78, MEPD_HUMAN)
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
9F204
Host
Mouse
Species Reactivity
Human
Form/Format
Tris-glycine and 150mM NaCl containing 0.05% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
This antibody is specific for thimet oligopeptidase. Species Crossreactivity: This antibody reacts with human protein. Other species have not been tested. Previous productions of this antibody have been shown to react with rat, rabbit, monkey and mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 3 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
78,840 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (2785506..2813599). Location: 19p13.3
OMIM
601117
3D Structure
ModBase 3D Structure for P52888
Immunogen
A synthetic peptide corresponding to residues 56-72 of human thimet oligopeptidase.
Cellular Localization
Cytoplasmic

Product Categories/Family for anti-THOP1 antibody

Applications Tested/Suitable for anti-THOP1 antibody
Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-THOP1 antibody
Suitable for use in Western Blot and Immunocytochemistry.

Other Notes

Small volumes of anti-THOP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for THOP1 purchase

MBS605765 is an antibody targeting THOP1. Also known as Thimet Oligopeptidase (TOP, Thimet Oligopeptidase 1, THOP1, EC 3.4.24.15, Endopeptidase 24.15, EP24.15, MP78, MEPD_HUMAN). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for THOP1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
thimet oligopeptidase
NCBI Official Synonym Full Names
thimet oligopeptidase 1
NCBI Official Symbol
THOP1
NCBI Official Synonym Symbols
TOP; MP78; EP24.15; MEPD_HUMAN
UniProt Protein Name
Thimet oligopeptidase
UniProt Synonym Protein Names
Endopeptidase 24.15; MP78
Protein Family
UniProt Gene Name
THOP1
UniProt Entry Name
THOP1_HUMAN
NCBI Protein Information
thimet oligopeptidase; endopeptidase 24.15

UniProt Comments for THOP1

THOP1: a protease that cleaves preferentially bonds with hydrophobic residues at P1, P2 and P3' and a small residue at P1' in substrates of 5 to 15 residues. Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.

Protein type: EC 3.4.24.15; Protease

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytoplasm

Molecular Function: protein binding; metalloendopeptidase activity; metal ion binding; peptide binding

Biological Process: peptide metabolic process; proteolysis
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-THOP1 antibody

 Reference Product  PubMed Publications
 AGTR1 antibody  >1 publications with THOP1 and AGTR1

Diseases associated with anti-THOP1 antibody

Organs/Tissues associated with anti-THOP1 antibody

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000