Mouse Anti-GLRA1 Monoclonal Antibody – Cat# MBS605777

Western blot detection of recombinant GST tagged human glycine receptor subunit alpha-1 using MBS605777.

Glycine Receptor Subunit Alpha 1 (GLRA1) Antibody – Mouse Monoclonal

Name: GLRA1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS605777
Price: 750 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS605777

Glycine receptor is a neurotransmitter-gated ion channel. When bound to its ligand, glycine, chloride conductance is increased and consequently inhibits neuronal firing. It is a pentameric receptor composed of alpha and beta subunits and localises to the cell… More details

$750 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Glycine Receptor Subunit alpha 1 (GLRA1), Monoclonal Antibody

Full Product Name

Glycine Receptor Subunit alpha 1 (Glycine Receptor 48kD Subunit, Glycine receptor strychnine-binding subunit, GLRA1)

Product Gene Name

anti-GLRA1 antibody

Product Synonym Names

Anti -Glycine Receptor Subunit alpha 1 (Glycine Receptor 48kD Subunit, Glycine receptor strychnine-binding subunit, GLRA1)

Clonality

Monoclonal

Isotype

IgG

Clone Number

9G364

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a lyophilized powder from PBS, pH7.2. Reconstitute with 100ul sterile ddH2O.

Purity/Purification

Affinity Purified
Purified by affinity chromatography.

Specificity

Recognizes human Glycine Receptor Subunit alpha 1.

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20 degree C. Aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

52,624 Da

Chromosome Location

Chromosome: 5; NC_000005.9 (151202074..151304397, complement). Location: 5q32

OMIM

138491

3D Structure

ModBase 3D Structure for P23415

Immunogen

Partial recombinant protein of human glycine receptor subunit alpha-1 (aa 121-221) with a GST tag.

Product Categories/Family for anti-GLRA1 antibody

Antibodies; Abs to Receptors

Applications Tested/Suitable for anti-GLRA1 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-GLRA1 antibody

Suitable for use in Western Blot and direct ELISA.

Other Notes

Small volumes of anti-GLRA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GLRA1 purchase

MBS605777 is an antibody targeting GLRA1. Also known as Glycine Receptor Subunit alpha 1 (Glycine Receptor 48kD Subunit, Glycine receptor strychnine-binding subunit, GLRA1). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for GLRA1. It may not necessarily be applicable to this product.

NCBI GI #

225903367

NCBI GeneID

2741

NCBI Accession #

NP_001139512.1

UniProt Primary Accession #

P23415

UniProt Secondary Accession #

Q14C77; Q6DJV9; B2R6T3

UniProt Related Accession #

P23415; Q14C71; Q6LC95

GenBank Nucleotide #

NM_001146040.1

NCBI Official Full Name

glycine receptor subunit alpha-1 isoform 1

NCBI Official Synonym Full Names

glycine receptor, alpha 1

NCBI Official Symbol

GLRA1

NCBI Official Synonym Symbols

STHE; MGC138878; MGC138879

UniProt Protein Name

Glycine receptor subunit alpha-1

UniProt Synonym Protein Names

Glycine receptor 48 kDa subunit; Glycine receptor strychnine-binding subunit

Protein Family

Glycine receptor

UniProt Gene Name

GLRA1

UniProt Entry Name

GLRA1_HUMAN

NCBI Protein Information

glycine receptor subunit alpha-1; OTTHUMP00000160616; OTTHUMP00000224176; glycine receptor 48 kDa subunit; glycine receptor strychnine-binding subunit

NCBI Summary for GLRA1

The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Two transcript variants encoding different isoforms have been found for this gene.

UniProt Comments for GLRA1

GLRA1: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). Defects in GLRA1 are the cause of hyperekplexia, hereditary, type 1 (HKPX1). A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub- subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Membrane protein, multi-pass; Membrane protein, integral; Transporter, ion channel

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: postsynaptic membrane; intracellular membrane-bound organelle; integral to plasma membrane; integral to membrane; plasma membrane; cell junction; external side of plasma membrane

Molecular Function: protein binding; transmitter-gated ion channel activity; extracellular-glycine-gated chloride channel activity; glycine binding; taurine binding

Biological Process: regulation of action potential; startle response; synaptic transmission, glycinergic; righting reflex; acrosome reaction; chloride transport; neurological control of breathing; adult walking behavior; neuromuscular process controlling posture; regulation of inhibitory postsynaptic membrane potential; regulation of membrane potential; visual perception; muscle contraction; negative regulation of transmission of nerve impulse; neuropeptide signaling pathway; ion transport; transmembrane transport

Disease: Hyperekplexia, Hereditary 1

Research Articles on GLRA1

1. ethanol appears to stabilize the GlyR model built on a presumably open form of the ligand-gated channel.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GLRA1 antibody

Products by Pathway	Pathway Diagram
Ion Channel Transport Pathway antibodies	Ion Channel Transport Pathway Diagram
Ligand-gated Ion Channel Transport Pathway antibodies	Ligand-gated Ion Channel Transport Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-GLRA1 antibody

Disease Name	Pubmed Publications
HYPEREKPLEXIA, HEREDITARY Antibodies	>18 publications with GLRA1 and HYPEREKPLEXIA, HEREDITARY
Brain Diseases Antibodies	>6 publications with GLRA1 and Brain Diseases
Lung Neoplasms Antibodies	>2 publications with GLRA1 and Lung Neoplasms
Neurodegenerative Diseases Antibodies	>1 publications with GLRA1 and Neurodegenerative Diseases
Learning Disorders Antibodies	>1 publications with GLRA1 and Learning Disorders
Asthma Antibodies	>1 publications with GLRA1 and Asthma
Brain Neoplasms Antibodies	>1 publications with GLRA1 and Brain Neoplasms
Dystonic Disorders Antibodies	>1 publications with GLRA1 and Dystonic Disorders

Organs/Tissues associated with anti-GLRA1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>18 publications with GLRA1 and Brain