Calmodulin-Dependent Protein Kinase II, Pan (CaMKII) Antibody – Rabbit Monoclonal

Function: A key regulator of plasticity in synaptic physiology and behavior, alterations in its activity produce pleiotrophic effects that involve synaptic transmission and development as well as various aspects of behavior. Directly modulates eag potassium channels. Ref.6 Ref.7

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation: CASK plays a role in regulation of CaMKII autophosphorylation. When complexed with CASK and in the presence Ca[2+]/CaM, autophosphorylation of Thr-287 causes constitutive activation of the kinase. In the absence of Ca[2+]/CaM, autophosphorylation of Thr-306 causes inactivation of the kinase. Ref.8

Subunit structure: Interacts with CASK. Ref.7

Tissue specificity: Expressed at a high level in the central nervous system during the late embryonic stage. In adults, expression is more abundant in the head than in the body. Ref.1 Ref.2

Post-translational modification: Autophosphorylation at Thr-287 is independent of autophosphorylation at Thr-306 and Thr-307.

Sequence similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Contains 1 protein kinase domain.