Brain-Specific Receptor-Like Protein A (EPHA5) Antibody – Rat Monoclonal

EphA5: Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino- hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, TK; EC 2.7.10.1; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; TK group; Eph family

Cellular Component: cell projection; membrane; rough endoplasmic reticulum; cell soma; perinuclear region of cytoplasm; dendrite; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: transferase activity; protein binding; protein-tyrosine kinase activity; GPI-linked ephrin receptor activity; transferase activity, transferring phosphorus-containing groups; ephrin receptor activity; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; kinase activity; ATP binding; protein kinase activity

Biological Process: nervous system development; axon guidance; regulation of GTPase activity; peptidyl-tyrosine phosphorylation; hippocampus development; activation of CREB transcription factor; negative regulation of synaptogenesis; protein amino acid phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; cAMP-mediated signaling; regulation of actin cytoskeleton organization and biogenesis; ephrin receptor signaling pathway; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway