Rabbit Anti-TYMP Monoclonal Antibody – Cat# MBS606212

Western blot analysis of extracts from COS cells, untransfected or transfected with human ECGF1, and human THP-1 cells, using MBS606212.

Thymidine Phosphorylase (TYMP) Antibody – Rabbit Monoclonal

Name: TYMP Antibody; Monoclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS606212
Price: 790 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS606212

Thymidine phosphorylase (TP) is a platelet-derived endothelial cell growth factor (PD-ECGF) that catalyzes the formation of thymine and 2-deoxy-D-ribose-1-phosphate from thymidine and orthophosphate. This intracellular enzyme is capable of both promoting… More details

$790 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Thymidine Phosphorylase (Tymp), Monoclonal Antibody

Full Product Name

Thymidine Phosphorylase (TYMP, ECGF1, Gliostatin, hPD-ECGF, MNGIE, PDECGF, PD-ECGF, Platelet-derived endothelial cell growth factor, TdRPase, TP)

Product Gene Name

anti-Tymp antibody

Product Synonym Names

Anti -Thymidine Phosphorylase (TYMP, ECGF1, Gliostatin, hPD-ECGF, MNGIE, PDECGF, PD-ECGF, Platelet-derived endothelial cell growth factor, TdRPase, TP)

Clonality

Monoclonal

Isotype

IgG

Clone Number

D69B12

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM NaCl, 100ug/ml BSA, 0.02% sodium azide and 50% glycerol.

Purity/Purification

Purified

Specificity

Recongnizes endogenous levels of human total TP/ECGF1 protein.

Preparation and Storage

Store at -20°C. Aliquots are stable for 12 months after receipt.
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Chromosome Location

Chromosome: 15; NC_000081.5 (89202362..89207467, complement). Location: 15 F1; 15 51.6 cM

3D Structure

ModBase 3D Structure for Q99N42

Immunogen

Synthetic peptide corresponding to residues surrounding Gln370 of human thymidine phosphorylase/ECGF1 protein (KLH-coupled).

Product Categories/Family for anti-Tymp antibody

Antibodies; Abs to Enzymes; Phosphorylase

Applications Tested/Suitable for anti-Tymp antibody

Western Blot (WB), Immunoprecipitation (IP)

Application Notes for anti-Tymp antibody

Suitable for use in Western Blot and Immunoprecipitation.
Dilution: Western Blot: 1:1000 Incubate membrane with diluted antibody in 5% w/v BSA, 1X TBS, 0.1% Tween-20 at 4 degree C with gentle shaking, overnight.
Immunoprecipitation: 1:100
Optimal dilutions should be determined by the researcher.
Other applications not tested.

Other Notes

Small volumes of anti-Tymp antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tymp purchase

MBS606212 is an antibody targeting Tymp. Also known as Thymidine Phosphorylase (TYMP, ECGF1, Gliostatin, hPD-ECGF, MNGIE, PDECGF, PD-ECGF, Platelet-derived endothelial cell growth factor, TdRPase, TP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Tymp. It may not necessarily be applicable to this product.

NCBI GI #

19923857

NCBI GeneID

72962

NCBI Accession #

NP_612175.1

UniProt Primary Accession #

Q99N42

UniProt Related Accession #

Q99N42

GenBank Nucleotide #

NM_138302.1

NCBI Official Full Name

thymidine phosphorylase

NCBI Official Synonym Full Names

thymidine phosphorylase

NCBI Official Symbol

Tymp

NCBI Official Synonym Symbols

Ecgf1; PDECGF; Pdgfec; PD-ECGF; 2900072D10Rik

UniProt Protein Name

Thymidine phosphorylase

UniProt Synonym Protein Names

TdRPase

Protein Family

Thymidine phosphorylase

UniProt Gene Name

Tymp

UniProt Synonym Gene Names

Ecgf1

UniProt Entry Name

TYPH_MOUSE

NCBI Protein Information

thymidine phosphorylase; TP; tdRPase; gliostatin; platelet derived growth factor, endothelial cell; endothelial cell growth factor 1 (platelet-derived)

UniProt Comments for Tymp

ECGF1: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Homodimer. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Protein type: Phosphorylase; Motility/polarity/chemotaxis; Xenobiotic Metabolism - drug metabolism - other enzymes; Transferase; EC 2.4.2.4; DNA replication; Nucleotide Metabolism - pyrimidine; Cytokine

Molecular Function: transferase activity; transferase activity, transferring glycosyl groups; thymidine phosphorylase activity; phosphorylase activity; transferase activity, transferring pentosyl groups; pyrimidine-nucleoside phosphorylase activity

Biological Process: organ morphogenesis; pyrimidine base metabolic process; metabolic process; chemotaxis; pyrimidine nucleoside metabolic process

Research Articles on Tymp

1. Thymidine phosphorylase and UPP1 double knockout mice showed increased thymidine and deoxyuridine in tissues and developed encephalopathy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Tymp antibody

Products by Pathway	Pathway Diagram
(deoxy)ribose Phosphate Degradation Pathway antibodies	(deoxy)ribose Phosphate Degradation Pathway Diagram
Bladder Cancer Pathway antibodies	Bladder Cancer Pathway Diagram
Bladder Cancer Pathway antibodies	Bladder Cancer Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
Drug Metabolism - Other Enzymes Pathway antibodies	Drug Metabolism - Other Enzymes Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Of Nucleotides Pathway antibodies	Metabolism Of Nucleotides Pathway Diagram
Pyrimidine Catabolism Pathway antibodies	Pyrimidine Catabolism Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram

Diseases associated with anti-Tymp antibody

Disease Name	Pubmed Publications
Mitochondrial Diseases Antibodies	>18 publications with Tymp and Mitochondrial Diseases
Muscular Diseases Antibodies	>12 publications with Tymp and Muscular Diseases
Central Nervous System Diseases Antibodies	>12 publications with Tymp and Central Nervous System Diseases
Neoplasms Antibodies	>8 publications with Tymp and Neoplasms
Cachexia Antibodies	>8 publications with Tymp and Cachexia
Carcinoma Antibodies	>4 publications with Tymp and Carcinoma
Vomiting Antibodies	>4 publications with Tymp and Vomiting
Pain Antibodies	>3 publications with Tymp and Pain
Hearing Loss Antibodies	>3 publications with Tymp and Hearing Loss
Adenocarcinoma Antibodies	>3 publications with Tymp and Adenocarcinoma

Organs/Tissues associated with anti-Tymp antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>5 publications with Tymp and Brain
Liver Antibodies	>4 publications with Tymp and Liver
Skin Antibodies	>2 publications with Tymp and Skin
Eye Antibodies	>2 publications with Tymp and Eye
Intestine Antibodies	>1 publications with Tymp and Intestine
Lung Antibodies	>1 publications with Tymp and Lung
Inner Ear Antibodies	>1 publications with Tymp and Inner Ear
Mammary Gland Antibodies	>1 publications with Tymp and Mammary Gland
Embryonic Tissue Antibodies	>1 publications with Tymp and Embryonic Tissue