• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Synuclein-Beta (SNCB) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS606587

Synuclein-beta is a 19kD, 134aa cytoplasmic phosphoprotein that is a member of a family of small, highly conserved proteins, including synucleins alpha, beta, and gamma (synoretin), localized predominantly in presynaptic nerve terminals in the brain.… More details

$1045 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Synuclein-beta (SNCB), Monoclonal Antibody
Full Product Name
Synuclein-beta (Phosphoneuroprotein 14, PNP14, SYN)
Product Gene Name
anti-SNCB antibody
Product Synonym Names
Anti -Synuclein-beta (Phosphoneuroprotein 14, PNP14, SYN)
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
9H182
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human Synuclein-beta.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
14,288 Da
Chromosome Location
chromosome: 5; Location: 5q35
OMIM
602569
3D Structure
ModBase 3D Structure for Q16143
Immunogen
Recombinant human Synuclein-beta aa47-120; Q16143 (E. coli).

Product Categories/Family for anti-SNCB antibody

Antibodies; Abs to Synuclein
Applications Tested/Suitable for anti-SNCB antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SNCB antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: ELISA: 0.5-1.0ug/ml
Western Blot: 2ug/ml
Immunohistochemistry: 25ug/ml

Western Blot (WB) of anti-SNCB antibody

Western Blot of human hippocampal tissue lysates using MBS606587 (2ug/ml), followed by IgG (HRP) anti-mouse. A specific band was detected for Synuclein-beta at ~20kD (as indicated). This experiment was conducted under reducing conditions.
Mouse Anti-SNCB Monoclonal Antibody – Cat# MBS606587

Other Notes

Small volumes of anti-SNCB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SNCB purchase

MBS606587 is an antibody targeting SNCB. Also known as Synuclein-beta (Phosphoneuroprotein 14, PNP14, SYN). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for SNCB. It may not necessarily be applicable to this product.

NCBI GI #
30582093
NCBI GeneID
6620
UniProt Primary Accession #
Q16143
UniProt Secondary Accession #
Q6IAX7
UniProt Related Accession #
Q16143; Q59GT0
NCBI Official Full Name
synuclein, beta
NCBI Official Synonym Full Names
synuclein, beta
NCBI Official Symbol
SNCB
NCBI Official Synonym Symbols
SNCB
UniProt Protein Name
Beta-synuclein
Protein Family
Beta-synuclein
UniProt Gene Name
SNCB
UniProt Entry Name
SYUB_HUMAN
NCBI Protein Information
beta-synuclein; OTTHUMP00000223369; OTTHUMP00000223370

NCBI Summary for SNCB

The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
Show more

UniProt Comments for SNCB

SNCB: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May play a role in neuronal plasticity, is abundant in neurofibrillary lesions of Alzheimer's patients. Highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: nucleoplasm; Golgi apparatus; growth cone; cell soma; mitochondrion; cytoplasm; terminal button; inclusion body

Molecular Function: phospholipase inhibitor activity; beta-tubulin binding; calcium ion binding; alpha-tubulin binding

Biological Process: synaptic transmission; negative regulation of catalytic activity; synapse organization and biogenesis; negative regulation of neuron apoptosis; dopamine metabolic process

Disease: Dementia, Lewy Body
Show more

Research Articles on SNCB

1. Gamma-synuclein protein is valuable for evaluation of progression of colorectal carcinoma; it is more sensitive to predict advanced stage and lymph node invasion when combined with either alpha- or beta-synuclein protein.
2. Our data confirm the fatty acid binding properties of alpha-syn, and to a lesser extent beta-syn, but suggest that gamma-syn does not share this same characteristic.
3. The aggregation behavior of alpha- and beta-synuclein as well as a series of chimeric variants were compared by exploring the structural transitions that occur in the presence of a widely used lipid mimetic, sodium dodecyl sulfate (SDS).
4. structural and functional properties of beta-synuclein were characterized using biochemical and bio-physical methods including: a functional assay, mass spectrometry, size exclusion chromatography, circular dichroism (CD), and fluorescence spectroscopy
5. Observational study of gene-disease association. (HuGE Navigator)
6. The accumulation of beta-synuclein was detectable only in the pons of Sandhoff disease cases. This differential accumulation of alpha- and beta-synucleins in human lipidoses may be related to functional differences between these two proteins.
7. A comparison of the structural and dynamic properties of the free states of all three synucleins, is reported in order to shed light on differences that may help to explain their different propensities to aggregate.
8. Of medulloblastomas, 76% have immunoreactivity for either alpha- or beta-synuclein or both; no immunoreactivity for gamma-synuclein is seen in medulloblastomas.
9. Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins
10. An 11-residue deletion in the lipid-binding domain of beta-synuclein leads to the destabilization of an entire segment of the micelle-bound helical structure containing the deletion site.
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SNCB antibody

 Reference Product  PubMed Publications
 SNCA antibody  >72 publications with SNCB and SNCA
 APP antibody  >2 publications with SNCB and APP

Diseases associated with anti-SNCB antibody

 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >46 publications with SNCB and Neurodegenerative Diseases
 Lewy Body Disease Antibodies  >18 publications with SNCB and Lewy Body Disease
 Neoplasms Antibodies  >11 publications with SNCB and Neoplasms
 Breast Neoplasms Antibodies  >8 publications with SNCB and Breast Neoplasms
 Carcinoma Antibodies  >5 publications with SNCB and Carcinoma
 Drug Toxicity Antibodies  >3 publications with SNCB and Drug Toxicity
 Genetic Diseases, Inborn Antibodies  >3 publications with SNCB and Genetic Diseases, Inborn
 Fibrosis Antibodies  >2 publications with SNCB and Fibrosis
 Gonadal Disorders Antibodies  >2 publications with SNCB and Gonadal Disorders
 Kidney Diseases Antibodies  >1 publications with SNCB and Kidney Diseases

Organs/Tissues associated with anti-SNCB antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >72 publications with SNCB and Nerve
 Brain Antibodies  >58 publications with SNCB and Brain
 Eye Antibodies  >1 publications with SNCB and Eye
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000