Specific Intracellular Adhesion Molecule Grabbing Nonintegrin R1 Antibody – Rat Monoclonal

SIGN-R1 is a specific marker for the identification of macrophage subpopulations present in the marginal zone of spleen (the so-called marginal zone macrophages (MZM)), in the lymph node medulla, and in some strains, in the peritoneal cavity. Mouse SIGN-R1 is a C-type lectin, like DC-SIGN which is expressed on human dendritic cells (DCs). However, mouse SIGN-R1 itself is not expressed on DCs. SIGN-R1 exists in an aggregated form, resistant to dissociation into monomers upon boiling in SDS under reducing conditions. SIGN-R1 mediates the uptake of encapsulated organisms and may be an important mediator for the uptake of microbes in both spleen and lymph node, particularly through the recognition of microbial polysaccharides. Uptake of FITC-labeled dextran by macrophages can be blocked both in vivo and in vitro by the monoclonal antibody. Therefore, the monoclonal antibody ER-TR9 can be used to study the uptake of polysaccharides by macrophages.

Small volumes of anti-Specific Intracellular Adhesion Molecule Grabbing Nonintegrin R1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS606657 is an antibody targeting Specific Intracellular Adhesion Molecule Grabbing Nonintegrin R1. Also known as Specific Intracellular Adhesion Molecule Grabbing Nonintegrin R1 (SIGN-R1, CD209 antigen-like protein B). Reactive in Mouse. Host: Rat.