Mouse Anti-NEFM Monoclonal Antibody – Cat# MBS606767

Neurofilament M, 160kD (NEFM) Antibody – Mouse Monoclonal

Name: NEFM Antibody; Monoclonal; Mouse; Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS606767
Price: 760 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS606767

Neurofilaments are a type of intermediate filament that serve as major elements of the cytoskeleton supporting the axon cytoplasm. They are the most abundant fibrillar components of the axon, being on average 3-10 times more frequent than axonal microtubules.… More details

$760 / 0.3 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Neurofilament M, 160kD (Nefm), Monoclonal Antibody

Full Product Name

Neurofilament M, 160kD (NF-M)

Product Gene Name

anti-Nefm antibody

Product Synonym Names

Anti -Neurofilament M, 160kD (NF-M)

Clonality

Monoclonal

Isotype

IgG

Clone Number

2Q168

Host

Mouse

Species Reactivity

Avian, Mammal, Rat

Form/Format

Supplied as a liquid with no preservatives.

Purity/Purification

Supernatant
Supernatant

Specificity

Recognizes an epitope from the last 84 amino acids of rat NF-M (145K). Reacts specifically with NF-M from a variety of mammalian and avian species.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

95,916 Da

Chromosome Location

Chromosome: 14; NC_000080.5 (68737602..68743061, complement). Location: 14 D1; 14

3D Structure

ModBase 3D Structure for P08553

Immunogen

Purified recombinant fusion protein containing the last 168 amino acids of rat NF-M.

Product Categories/Family for anti-Nefm antibody

Antibodies; Abs to Neurofilament

Applications Tested/Suitable for anti-Nefm antibody

Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-Nefm antibody

Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1:1000-1:2000
Immunohistochemistry (frozen): 1:50-1:1000 4% PFA fixed tissue sections
Optimal dilutions to be determined by researcher.

Other Notes

Small volumes of anti-Nefm antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nefm purchase

MBS606767 is an antibody targeting Nefm. Also known as Neurofilament M, 160kD (NF-M). Reactive in Avian, Mammal, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Nefm. It may not necessarily be applicable to this product.

NCBI GI #

112363107

NCBI GeneID

18040

NCBI Accession #

NP_032717.2

UniProt Primary Accession #

P08553

UniProt Secondary Accession #

Q0VDM8; Q3HRJ6; Q3TNS4; Q3TPK2; Q61961; Q8BQ20; A2VCT5

UniProt Related Accession #

P08553

GenBank Nucleotide #

NM_008691.2

NCBI Official Full Name

neurofilament medium polypeptide

NCBI Official Synonym Full Names

neurofilament, medium polypeptide

NCBI Official Symbol

Nefm

NCBI Official Synonym Symbols

Nfm; NF-M; Nef3; NF160; NF165

UniProt Protein Name

Neurofilament medium polypeptide

UniProt Synonym Protein Names

160 kDa neurofilament protein; Neurofilament 3; Neurofilament triplet M protein

Protein Family

Neurofilament medium polypeptide

UniProt Gene Name

Nefm

UniProt Synonym Gene Names

Nef3; Nfm

UniProt Entry Name

NFM_MOUSE

NCBI Protein Information

neurofilament medium polypeptide; neurofilament-M; OTTMUSP00000017611; neurofilament 3, medium; neurofilament protein M; 160 kDa neurofilament protein; neurofilament triplet M protein

UniProt Comments for Nefm

NFM: a neurofilament intermediate filament protein. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. The levels of phosphorylation are altered developmentally and coincident with a change in the neurofilament function.

Protein type: Cytoskeletal

Cellular Component: neuron projection; cytoskeleton; axon; cell; neurofilament; intermediate filament; intracellular; neuromuscular junction; myelin sheath

Molecular Function: structural molecule activity

Biological Process: neurofilament cytoskeleton organization and biogenesis; axon cargo transport; regulation of axon diameter; intermediate filament cytoskeleton organization and biogenesis; intermediate filament bundle assembly; microtubule cytoskeleton organization and biogenesis

Research Articles on Nefm

1. results obtained in mouse model for leprous neuropathy indicate biochemical alterations in neurofilaments, i.e., hyperphosphorylation of NF-H and NF-M

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Nefm antibody

Products by Pathway	Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram

Diseases associated with anti-Nefm antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>2 publications with Nefm and Neoplasms
Nervous System Diseases Antibodies	>2 publications with Nefm and Nervous System Diseases
Nervous System Malformations Antibodies	>1 publications with Nefm and Nervous System Malformations
Brain Neoplasms Antibodies	>1 publications with Nefm and Brain Neoplasms
Hereditary Sensory and Motor Neuropathy Antibodies	>1 publications with Nefm and Hereditary Sensory and Motor Neuropathy
Nervous System Neoplasms Antibodies	>1 publications with Nefm and Nervous System Neoplasms
Polyneuropathies Antibodies	>1 publications with Nefm and Polyneuropathies
Peripheral Nervous System Diseases Antibodies	>1 publications with Nefm and Peripheral Nervous System Diseases

Organs/Tissues associated with anti-Nefm antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>1 publications with Nefm and Brain