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Necrostatin-1 (5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone, Methylthiohydantoin-DL-tryptophan, Nec-1)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6069390

Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in the activation of necroptosis (EC50 = 180nM) More details

$400 / 5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Necrostatin-1, Biochemical
Full Product Name
Necrostatin-1 (5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone, Methylthiohydantoin-DL-tryptophan, Nec-1)
Form/Format
Supplied as a yellow solid.
Purity/Purification
Highly Purified
~98% (TLC)
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with DMSO or EtOH. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
259.33
CAS Number
4311-88-0
Molecular Formula
C13H13N3OS
Solubility
DMSO (~25mg/ml) or EtOH (~6mg/ml)

Product Categories/Family for Necrostatin-1 biochemical

Biochemicals; Biochem-Inhibitors

Testing Data of Necrostatin-1 biochemical

Necrostatin-1 (5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone, Methylthiohydantoin-DL-tryptophan, Nec-1) Biochemical – Cat# MBS6069390

Other Notes

Small volumes of Necrostatin-1 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Necrostatin-1 purchase

MBS6069390 is a biochemical targeting Necrostatin-1. Also known as Necrostatin-1 (5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone, Methylthiohydantoin-DL-tryptophan, Nec-1).
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