Mouse Anti-GIP Monoclonal Antibody – Cat# MBS607161

Gastric Inhibitory Polypeptide (GIP) Antibody – Mouse Monoclonal

Name: GIP Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS607161
Price: 1940 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS607161

Human gastric inhibitory polypeptide (GIP) is a 42aa peptide belonging to the glucagon-secretin family of peptide hormones. It is secreted by endocrine cells in the duodenal mucosa and stimulates glucose-dependent insulin secretion as well as GLP-1 release… More details

$1940 / 0.1 mL +2 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Gastric Inhibitory Polypeptide (GIP), Monoclonal Antibody

Full Product Name

Gastric Inhibitory Polypeptide (GIP) (BSA & Azide Free)

Product Gene Name

anti-GIP antibody

Product Synonym Names

Anti -Gastric Inhibitory Polypeptide (GIP) (BSA & Azide Free)

Clonality

Monoclonal

Isotype

IgG1,k

Clone Number

6F106

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.4. No preservative added. Aavailable with azide. See G2019F.

Purity/Purification

Affinity Purified
Purified by Protein A/G affinity chromatography.

Specificity

Recognizes human Gastric Inhibitory Polypeptide (GIP). Binds free GIP in solution. Crossreacts up to 10% with PACAP and human GLP-2. < 0.1% crossreactivity with glucagon, GLP-1 and VIP.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

17,108 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (47035918..47045955, complement). Location: 17q21.3-q22

OMIM

137240

3D Structure

ModBase 3D Structure for P09681

Immunogen

Synthetic human gastric inhibitory polypeptide.

Hybridoma

Sp2/mIL-6 myeloma cells with spleen cells from NMRI x Balb/c mice.

Product Categories/Family for anti-GIP antibody

Antibodies; Abs to Hormones; Steroids

Applications Tested/Suitable for anti-GIP antibody

ELISA (EL/EIA), Immunohistochemistry (IHC)

Application Notes for anti-GIP antibody

Suitable for use in ELISA and Immunohistochemistry.
Dilution: ELISA: 1:2000; Using glutaraldehyde-linked GIP-OA (molar ratio 4:1) coated at 1ug/ml (or GIP coated directly at 2ug/ml). G2019F binds free GIP in solution.

Other Notes

Small volumes of anti-GIP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GIP purchase

MBS607161 is an antibody targeting GIP. Also known as Gastric Inhibitory Polypeptide (GIP) (BSA & Azide Free). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for GIP. It may not necessarily be applicable to this product.

NCBI GI #

183213

NCBI GeneID

2695

UniProt Primary Accession #

P09681

UniProt Secondary Accession #

Q4VB42; Q6NTD3

UniProt Related Accession #

P09681

NCBI Official Full Name

gastric inhibitory polypeptide

NCBI Official Synonym Full Names

gastric inhibitory polypeptide

NCBI Official Symbol

GIP

NCBI Official Synonym Symbols

GIP

UniProt Protein Name

Gastric inhibitory polypeptide

UniProt Synonym Protein Names

Glucose-dependent insulinotropic polypeptide

Protein Family

Copia protein

UniProt Gene Name

GIP

UniProt Entry Name

GIP_HUMAN

NCBI Protein Information

gastric inhibitory polypeptide; OTTHUMP00000219839; glucose-dependent insulinotropic polypeptide

NCBI Summary for GIP

This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq]

UniProt Comments for GIP

GIP: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion. Belongs to the glucagon family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q21.3-q22

Cellular Component: extracellular space; cell soma; endoplasmic reticulum lumen; extracellular region

Molecular Function: hormone activity

Biological Process: response to drug; response to peptide hormone stimulus; adult locomotory behavior; positive regulation of insulin secretion; female pregnancy; sensory perception of pain; response to lipid; signal transduction; response to amino acid stimulus; response to organic cyclic substance; endocrine pancreas development; memory; response to starvation; response to selenium ion; cellular protein metabolic process; response to glucose stimulus; response to axon injury; regulation of insulin secretion

Research Articles on GIP

1. We report that the human GIP locus was differentially selected in East Asians about 8100 years ago based on the analysis of a nonsynonymous SNP (rs2291725).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GIP antibody

Reference Product	PubMed Publications
GIPR antibody	>62 publications with GIP and GIPR

Pathways associated with anti-GIP antibody

Products by Pathway	Pathway Diagram
Class B/2 (Secretin Family Receptors) Pathway antibodies	Class B/2 (Secretin Family Receptors) Pathway Diagram
Diabetes Pathways antibodies	Diabetes Pathways Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Glucagon-type Ligand Receptors Pathway antibodies	Glucagon-type Ligand Receptors Pathway Diagram
Incretin Synthesis, Secretion, And Inactivation Pathway antibodies	Incretin Synthesis, Secretion, And Inactivation Pathway Diagram
Integration Of Energy Metabolism Pathway antibodies	Integration Of Energy Metabolism Pathway Diagram
Regulation Of Insulin Secretion Pathway antibodies	Regulation Of Insulin Secretion Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with anti-GIP antibody

Disease Name	Pubmed Publications
Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules Antibodies	>2426 publications with GIP and Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules
Diabetes Mellitus, Type 2 Antibodies	>311 publications with GIP and Diabetes Mellitus, Type 2
Obesity Antibodies	>217 publications with GIP and Obesity
Insulin Resistance Antibodies	>153 publications with GIP and Insulin Resistance
Neoplasms Antibodies	>144 publications with GIP and Neoplasms
Mental Disorders Antibodies	>72 publications with GIP and Mental Disorders
Weight Loss Antibodies	>64 publications with GIP and Weight Loss
Adenoma Antibodies	>55 publications with GIP and Adenoma
Diabetes Complications Antibodies	>52 publications with GIP and Diabetes Complications
Neurologic Manifestations Antibodies	>40 publications with GIP and Neurologic Manifestations

Organs/Tissues associated with anti-GIP antibody

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>399 publications with GIP and Intestine
Stomach Antibodies	>146 publications with GIP and Stomach