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CCR9 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS607361

MBS607361 is an antibody targeting CCR9. Also known as CCR9 (C-C chemokine receptor type 9, CC-CKR-9, C-C CKR-9, CCR-9, CDw199, GPR28, GPR-9-6, G-protein coupled receptor 28). Reactive in Mouse. Host: Rat. More details

$830 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCR9, Monoclonal Antibody
Full Product Name
CCR9 (C-C chemokine receptor type 9, CC-CKR-9, C-C CKR-9, CCR-9, CDw199, GPR28, GPR-9-6, G-protein coupled receptor 28)
Product Gene Name
anti-CCR9 antibody
Product Synonym Names
Anti -CCR9 (C-C chemokine receptor type 9, CC-CKR-9, C-C CKR-9, CCR-9, CDw199, GPR28, GPR-9-6, G-protein coupled receptor 28)
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
10B2187
Host
Rat
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes mouse CDw199.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
42,016 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (45927996..45944667). Location: 3p21.3
OMIM
604738
3D Structure
ModBase 3D Structure for P51686
Immunogen
25 aa from the amino terminal of murine CCR9, coupled to KLH.

Product Categories/Family for anti-CCR9 antibody

Antibodies; Abs to G Protein Receptors
Applications Tested/Suitable for anti-CCR9 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CCR9 antibody
Suitable for use in Flow Cytometry.
Dilution: Flow Cytometry: 1:25-1:200; 10ul labels 10e6 cells in 100ul

Testing Data of anti-CCR9 antibody

Staining of mouse thymocytes with unconjugated Rat anti Mouse CDw199
Rat Anti-CCR9 Monoclonal Antibody – Cat# MBS607361

Testing Data of anti-CCR9 antibody

Staining of mouse thymocytes with Rat anti Mouse CDw199:FITC
Rat Anti-CCR9 Monoclonal Antibody, Testing Data – Cat# MBS607361

Testing Data of anti-CCR9 antibody

Staining of mouse thymocytes with Rat anti Mouse CDw199:Alexa Fluor ®488
Rat Anti-CCR9 Monoclonal Antibody, Testing Data – Cat# MBS607361

Testing Data of anti-CCR9 antibody

Staining of mouse thymocytes with unconjugated Rat anti Mouse CDw199:RPE
Rat Anti-CCR9 Monoclonal Antibody, Testing Data – Cat# MBS607361

Testing Data of anti-CCR9 antibody

Staining of mouse thymocytes with Rat anti Mouse CDw199:Alexa Fluor ®647
Rat Anti-CCR9 Monoclonal Antibody, Testing Data – Cat# MBS607361

Other Notes

Small volumes of anti-CCR9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CCR9. It may not necessarily be applicable to this product.

NCBI GI #
14043044
NCBI GeneID
10803
NCBI Accession #
NP_006632.2
UniProt Primary Accession #
P51686
UniProt Secondary Accession #
Q4VBM3; Q549E0; Q9UQQ6
UniProt Related Accession #
P51686; Q9UN87
GenBank Nucleotide #
NM_006641.3
NCBI Official Full Name
C-C chemokine receptor type 9 isoform B
NCBI Official Synonym Full Names
chemokine (C-C motif) receptor 9
NCBI Official Symbol
CCR9
NCBI Official Synonym Symbols
GPR28; CDw199; GPR-9-6
UniProt Protein Name
C-C chemokine receptor type 9
UniProt Synonym Protein Names
G-protein coupled receptor 28; GPR-9-6
Protein Family
C-C chemokine receptor
UniProt Gene Name
CCR9
UniProt Synonym Gene Names
GPR28
UniProt Entry Name
CCR9_HUMAN
NCBI Protein Information
C-C chemokine receptor type 9; CC-CKR-9; OTTHUMP00000164653; OTTHUMP00000164654; G protein-coupled receptor 28

NCBI Summary for CCR9

The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. [provided by RefSeq]
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UniProt Comments for CCR9

CCR9: Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cellular defense response; immune response; chemotaxis
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Research Articles on CCR9

1. CCR9+ Th cells are a subset of IL-21-producing T helper cells that influence regional specification of autoimmune diseases that affect accessory organs of the digestive system

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCR9 antibody

 Reference Product  PubMed Publications
 CCL25 antibody  >104 publications with CCR9 and CCL25

Pathways associated with anti-CCR9 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram

Diseases associated with anti-CCR9 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >51 publications with CCR9 and Inflammation
 Neoplasm Metastasis Antibodies  >12 publications with CCR9 and Neoplasm Metastasis
 Lung Diseases Antibodies  >8 publications with CCR9 and Lung Diseases
 Carcinoma Antibodies  >7 publications with CCR9 and Carcinoma
 Breast Neoplasms Antibodies  >4 publications with CCR9 and Breast Neoplasms
 Liver Neoplasms Antibodies  >4 publications with CCR9 and Liver Neoplasms
 Skin Neoplasms Antibodies  >4 publications with CCR9 and Skin Neoplasms
 Lung Neoplasms Antibodies  >3 publications with CCR9 and Lung Neoplasms
 Body Weight Changes Antibodies  >2 publications with CCR9 and Body Weight Changes
 Mycoses Antibodies  >2 publications with CCR9 and Mycoses

Organs/Tissues associated with anti-CCR9 antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >106 publications with CCR9 and Intestine
 Thymus Antibodies  >76 publications with CCR9 and Thymus
 Mixed Antibodies  >3 publications with CCR9 and Mixed
 Stomach Antibodies  >3 publications with CCR9 and Stomach
 Kidney Antibodies  >2 publications with CCR9 and Kidney
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