Rat Anti-SLAMF7 Monoclonal Antibody – Cat# MBS607425

DX5+ splenocytes were stained with MBS607425 or isotype control followed by APC-conjugated anti-rat antibody.

SLAMF7 Antibody – Rat Monoclonal

Name: SLAMF7 Antibody; Monoclonal; Rat; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS607425
Price: 1030 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS607425

CRACC, also known as CSI (CD2 subset I), is a type I transmembrane protein belonging to the CD2 subset of the Ig superfamily. CRACC is expressed on most NK cells and subsets of CD8 + cells, CD4 + cells and B cells. CRACC may play a role in the activation and… More details

$1030 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CRACC (SLAMF7), Monoclonal Antibody

Full Product Name

CRACC (SLAMF7, SLAM family member 7, 19A, CSI, CD2-like receptor-activating cytotoxic cells, CD2 subset 1, CD319, CS1, Membrane protein FOAP-12, Novel Ly9, Protein 19A, UNQ576/PRO1138)

Product Gene Name

anti-SLAMF7 antibody

Product Synonym Names

Anti -CRACC (SLAMF7, SLAM family member 7, 19A, CSI, CD2-like receptor-activating cytotoxic cells, CD2 subset 1, CD319, CS1, Membrane protein FOAP-12, Novel Ly9, Protein 19A, UNQ576/PRO1138)

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

9H102

Host

Rat

Species Reactivity

Mouse

Form/Format

Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.

Purity/Purification

Affinity Purified
Purified by Protein G affinity chromatography.

Specificity

Recognizes recombinant mouse CRACC in Direct ELISAs. Shows no cross-reactivity with recombinant human CRACC.

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

37,421 Da

Chromosome Location

chromosome: 1; Location: 1q23.1-q24.1

OMIM

606625

3D Structure

ModBase 3D Structure for Q9NQ25

Immunogen

Recombinant corresponding to aa 22-224 from mouse CRACC expressed in CHO cells (Q8BHK6).

Product Categories/Family for anti-SLAMF7 antibody

Antibodies; Abs to Matrix Metalloproteinases

Applications Tested/Suitable for anti-SLAMF7 antibody

ELISA (EL/EIA), Flow Cytometry (FC/FACS)

Application Notes for anti-SLAMF7 antibody

Suitable for Direct ELISA and Flow Cytometry.
Dilution: Flow Cytometry: 25ug/ml. Use 10ul to label 1-2.5x10e5 cells in a total reaction volume <200ul.
Direct ELISA: 0.5-1ug/ml. The detection limit is ~1ng/well.

Other Notes

Small volumes of anti-SLAMF7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLAMF7 purchase

MBS607425 is an antibody targeting SLAMF7. Also known as CRACC (SLAMF7, SLAM family member 7, 19A, CSI, CD2-like receptor-activating cytotoxic cells, CD2 subset 1, CD319, CS1, Membrane protein FOAP-12, Novel Ly9, Protein 19A, UNQ576/PRO1138). Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for SLAMF7. It may not necessarily be applicable to this product.

NCBI GI #

16589011

NCBI GeneID

57823

UniProt Primary Accession #

Q9NQ25

UniProt Secondary Accession #

Q8N6Y8; Q8ND32; Q9NY08; Q9NY23

UniProt Related Accession #

Q9NQ25

NCBI Official Full Name

CD2-like receptor activating cytotoxic cells

NCBI Official Synonym Full Names

SLAM family member 7

NCBI Official Symbol

SLAMF7

NCBI Official Synonym Symbols

19A; CS1; CD319; CRACC; SLAMF7

UniProt Protein Name

SLAM family member 7

UniProt Synonym Protein Names

CD2 subset 1; CD2-like receptor-activating cytotoxic cells; CRACC; Membrane protein FOAP-12; Novel Ly9; Protein 19A

Protein Family

SLAM family

UniProt Gene Name

SLAMF7

UniProt Synonym Gene Names

CS1

UniProt Entry Name

SLAF7_HUMAN

NCBI Protein Information

SLAM family member 7; protein 19A; CD2 subset 1; 19A24 protein; membrane protein FOAP-12; CD2-like receptor activating cytotoxic cells; CD2-like receptor-activating cytotoxic cells; novel LY9 (lymphocyte antigen 9) like protein

UniProt Comments for SLAMF7

SLAMF7: Isoform 1 mediates NK cell activation through a SH2D1A- independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.1-q24.1

Cellular Component: integral to membrane

Molecular Function: receptor activity

Biological Process: natural killer cell mediated cytotoxicity; natural killer cell activation; cell adhesion

Research Articles on SLAMF7

1. altered expression of splice variants of CS1 and 2B4 that mediate differential signalling in PBMC from patients with SLE.
2. Data show that pair-wise ligations of 2B4 with DNAM-1 and/or NKG2D lead to increased effector functions of primary CD4(+)CD28(-) T cells to suboptimal levels of anti-CD3 stimulation.
3. CS1 was expressed at adhesion-promoting uropod membranes of polarized Multiple Myeloma cells, andis required for MM cell adhesion to bone marrow stromal cells
4. HuLuc63 eliminates myeloma cells, at least in part, via NK-mediated ADCC and shows the therapeutic potential of targeting CS1 with HuLuc63 for the treatment of multiple myeloma.
5. Observational study of gene-disease association. (HuGE Navigator)
6. 2B4, NTB-A and CRACC have roles in the regulation of Natural Killer cell function [review]
7. CS1 may play a role in the regulation of B lymphocyte proliferation during immune responses
8. CS1-L and CS1-S may differentially regulate human NK cell functions
9. blocking the engagement of 2B4, NTB-A and CRACC has no effect on the proliferation or development of the cytotoxic potential of NK cells but triggering by their physiological ligands on MHC class I-negative target cells induces potent NK cell cytotoxicity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLAMF7 antibody

Reference Product	PubMed Publications
SH2D1A antibody	>5 publications with SLAMF7 and SH2D1A

Diseases associated with anti-SLAMF7 antibody

Disease Name	Pubmed Publications
Encephalomyelitis, Autoimmune, Experimental Antibodies	>1 publications with SLAMF7 and Encephalomyelitis, Autoimmune, Experimental

Organs/Tissues associated with anti-SLAMF7 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>22 publications with SLAMF7 and Blood
Bone Antibodies	>6 publications with SLAMF7 and Bone
Pharynx Antibodies	>1 publications with SLAMF7 and Pharynx
Brain Antibodies	>1 publications with SLAMF7 and Brain
Spleen Antibodies	>1 publications with SLAMF7 and Spleen