Rabbit Anti-GRIA3 Monoclonal Antibody – Cat# MBS607601

Western blot analysis of extracts from mouse and rat brains using MBS607601.

GRIA3 Antibody – Rabbit Monoclonal

Name: GRIA3 Antibody; Monoclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS607601
Price: 815 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS607601

AMPA- (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), kainite- and NMDA- (N-methyl-D-aspartate) receptors are the three main families of ionotropic glutamate-gated ion channels. AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4)… More details

$815 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GluR3 (GRIA3), Monoclonal Antibody

Full Product Name

GluR3 (Glutamate Receptor 3, GluR3, GluR-3, AMPA-selective Glutamate Receptor 3, AMPA3, GLURC, GluR-C, GluR-K3, Ionotropic Glutamate Receptor AMPA 3, Gria3, MRX94)

Product Gene Name

anti-GRIA3 antibody

Product Synonym Names

Anti -GluR3 (Glutamate Receptor 3, GluR3, GluR-3, AMPA-selective Glutamate Receptor 3, AMPA3, GLURC, GluR-C, GluR-K3, Ionotropic Glutamate Receptor AMPA 3, Gria3, MRX94)

Clonality

Monoclonal

Isotype

IgG

Clone Number

10E24

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM NaCl, 100ug/ml BSA, 0.02% sodium azide and 50% glycerol.

Purity/Purification

Purified
Purified

Specificity

Recongnizes endogenous levels of human total GluR 3 protein. Species crossreactivity: mouse, rat.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

101,157 Da

Chromosome Location

Chromosome: X; NC_000023.10 (122318096..122624766). Location: Xq25

OMIM

300699

3D Structure

ModBase 3D Structure for P42263

Immunogen

Synthetic peptide corresponding to residues surrounding Pro590 of human GluR 3 protein (KLH-coupled).

Product Categories/Family for anti-GRIA3 antibody

Antibodies; Abs to Receptors

Applications Tested/Suitable for anti-GRIA3 antibody

Western Blot (WB), Immunoprecipitation (IP)

Application Notes for anti-GRIA3 antibody

Suitable for use in Western Blot and Immunoprecipitation.
Dilution: Western Blot: 1:10-1:50 Incubate membrane with diluted antibody in 5% w/v BSA, 1X TBS, 0.1% Tween-20 at 4 degree C with gentle shaking, overnight.
Immunoprecipitation: 1:50

Other Notes

Small volumes of anti-GRIA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRIA3 purchase

MBS607601 is an antibody targeting GRIA3. Also known as GluR3 (Glutamate Receptor 3, GluR3, GluR-3, AMPA-selective Glutamate Receptor 3, AMPA3, GLURC, GluR-C, GluR-K3, Ionotropic Glutamate Receptor AMPA 3, Gria3, MRX94). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GRIA3. It may not necessarily be applicable to this product.

NCBI GI #

163659858

NCBI GeneID

2892

NCBI Accession #

NP_000819.3

UniProt Primary Accession #

P42263

UniProt Secondary Accession #

Q4VXD5; Q4VXD6; Q9HDA0; Q9HDA1; Q9HDA2; D3DTF1

UniProt Related Accession #

P42263; Q17R51; Q4TT43; Q5XKG2; Q9P0H1; Q9P0H2; Q9UHA9

GenBank Nucleotide #

NM_000828.4

NCBI Official Full Name

glutamate receptor 3 isoform 2

NCBI Official Synonym Full Names

glutamate receptor, ionotrophic, AMPA 3

NCBI Official Symbol

GRIA3

NCBI Official Synonym Symbols

GLUR3; GLURC; GluA3; MRX94; GLUR-C; GLUR-K3

UniProt Protein Name

Glutamate receptor 3

UniProt Synonym Protein Names

AMPA-selective glutamate receptor 3; GluR-C; GluR-K3; Glutamate receptor ionotropic, AMPA 3

Protein Family

Glutamate receptor

UniProt Gene Name

GRIA3

UniProt Synonym Gene Names

GLUR3; GLURC

UniProt Entry Name

GRIA3_HUMAN

NCBI Protein Information

glutamate receptor 3; gluR-3; dJ1171F9.1; OTTHUMP00000024261; OTTHUMP00000024262; glutamate receptor C; glutamate receptor subunit 3; AMPA-selective glutamate receptor 3; glutamate receptor ionotropic, AMPA 3

NCBI Summary for GRIA3

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq]

UniProt Comments for GRIA3

GluR3: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Interacts with protein kinase C-alpha binding protein. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated

Chromosomal Location of Human Ortholog: Xq25

Cellular Component: postsynaptic membrane; dendrite; plasma membrane; cell junction

Molecular Function: extracellular-glutamate-gated ion channel activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Biological Process: synaptic transmission, glutamatergic; synaptic transmission; glutamate signaling pathway; transport; ionotropic glutamate receptor signaling pathway

Disease: Mental Retardation, X-linked, Syndromic, Wu Type

Research Articles on GRIA3

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GRIA3 antibody

Reference Product	PubMed Publications
GRIA2 antibody	>4 publications with GRIA3 and GRIA2

Pathways associated with anti-GRIA3 antibody

Products by Pathway	Pathway Diagram
Activation Of AMPA Receptors Pathway antibodies	Activation Of AMPA Receptors Pathway Diagram
Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies	Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway antibodies	Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Hypothetical Network For Drug Addiction Pathway antibodies	Hypothetical Network For Drug Addiction Pathway Diagram
Long-term Depression Pathway antibodies	Long-term Depression Pathway Diagram
Long-term Depression Pathway antibodies	Long-term Depression Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-GRIA3 antibody

Disease Name	Pubmed Publications
Mental Disorders Antibodies	>11 publications with GRIA3 and Mental Disorders
Genetic Diseases, Inborn Antibodies	>5 publications with GRIA3 and Genetic Diseases, Inborn
Mental Retardation, X-Linked Antibodies	>5 publications with GRIA3 and Mental Retardation, X-Linked
Anxiety Disorders Antibodies	>4 publications with GRIA3 and Anxiety Disorders
Schizophrenia Antibodies	>3 publications with GRIA3 and Schizophrenia
Epilepsy Antibodies	>2 publications with GRIA3 and Epilepsy
Neoplasms Antibodies	>1 publications with GRIA3 and Neoplasms
Cognition Disorders Antibodies	>1 publications with GRIA3 and Cognition Disorders
Genital Diseases, Male Antibodies	>1 publications with GRIA3 and Genital Diseases, Male
Seizures Antibodies	>1 publications with GRIA3 and Seizures

Organs/Tissues associated with anti-GRIA3 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>9 publications with GRIA3 and Brain
Embryonic Tissue Antibodies	>1 publications with GRIA3 and Embryonic Tissue