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Interleukin 33 Propeptide (IL33) Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS607622

IL-33, also known as NF-HEV and DVS 27, is an IL-1 family member that is constitutively expressed in smooth muscle and airway epithelia and is upregulated by IL-1 alpha or beta in arterial smooth muscle, dermal fibroblasts and keratinocytes. IL-33 is… More details

$1015 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Interleukin 33 Propeptide (Il33), Monoclonal Antibody
Full Product Name
Interleukin 33 Propeptide (IL-33, C9orf26, DKFZp586H0523, DVS27, IL1F11, IL-1F11, Interleukin-1 Family Member 11, Interleukin-33, NFEHEV, NFHEV, NF-HEV, Nuclear Factor from High Endothelial Venules, RP11-575C20.2)
Product Gene Name
anti-Il33 antibody
Product Synonym Names
Anti -Interleukin 33 Propeptide (IL-33, C9orf26, DKFZp586H0523, DVS27, IL1F11, IL-1F11, Interleukin-1 Family Member 11, Interleukin-33, NFEHEV, NFHEV, NF-HEV, Nuclear Factor from High Endothelial Venules, RP11-575C20.2)
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
9H138
Host
Rat
Species Reactivity
Mouse
Form/Format
Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with 0.2ml sterile 40-50% glycerol, PBS.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes mouse IL-33 Propeptide. Does not crossreact with mouse or human rIL-33, or the pro region of human rIL-33.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, PBS. Aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
29,991 Da
Chromosome Location
Chromosome: 19; NC_000085.5 (29999604..30035205). Location: 19; 19 C2
3D Structure
ModBase 3D Structure for Q8BVZ5
Immunogen
Recombinant mouse IL-33 Propeptide aa1-108; Q8BVZ5 (E. coli).

Product Categories/Family for anti-Il33 antibody

Antibodies; Abs to Interleukin
Applications Tested/Suitable for anti-Il33 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Il33 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 0.5-1.0ug/ml; Detection limit for rmIL-33 is ~5ng/well.
Western Blot: 2ug/ml

Other Notes

Small volumes of anti-Il33 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Il33 purchase

MBS607622 is an antibody targeting Il33. Also known as Interleukin 33 Propeptide (IL-33, C9orf26, DKFZp586H0523, DVS27, IL1F11, IL-1F11, Interleukin-1 Family Member 11, Interleukin-33, NFEHEV, NFHEV, NF-HEV, Nuclear Factor from High Endothelial Venules, RP11-575C20.2). Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for Il33. It may not necessarily be applicable to this product.

NCBI GI #
68565902
NCBI GeneID
77125
UniProt Primary Accession #
Q8BVZ5
UniProt Secondary Accession #
Q2YEJ4; Q3TQN0; Q99L46
UniProt Related Accession #
Q8BVZ5
NCBI Official Full Name
Interleukin-33
NCBI Official Synonym Full Names
interleukin 33
NCBI Official Symbol
Il33
NCBI Official Synonym Symbols
Il-33; Il1f11; NF-HEV; 9230117N10Rik
UniProt Protein Name
Interleukin-33
Protein Family
Interleukin
UniProt Gene Name
Il33
UniProt Entry Name
IL33_MOUSE
NCBI Protein Information
interleukin-33; OTTMUSP00000035769; nuclear factor from high endothelial venules

UniProt Comments for Il33

IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Cellular Component: extracellular space; extracellular region; cytoplasmic vesicle; chromosome; nucleus

Molecular Function: cytokine activity

Biological Process: negative regulation of T-helper 1 type immune response; positive regulation of T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; negative regulation of leukocyte migration; positive regulation of interleukin-4 production; negative regulation of immunoglobulin secretion; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-13 production; defense response to virus; positive regulation of interleukin-5 production; positive regulation of macrophage activation; positive regulation of inflammatory response
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Research Articles on Il33

1. Data show that MC3T3-E1 osteoblast-like cells constitutively express ST2L mRNA, and IL-33.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Il33 antibody

 Products by Pathway  Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram

Diseases associated with anti-Il33 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >66 publications with Il33 and Inflammation
 Asthma Antibodies  >31 publications with Il33 and Asthma
 Lung Diseases Antibodies  >25 publications with Il33 and Lung Diseases
 Arthritis, Rheumatoid Antibodies  >10 publications with Il33 and Arthritis, Rheumatoid
 Skin Diseases Antibodies  >8 publications with Il33 and Skin Diseases
 Myocardial Infarction Antibodies  >6 publications with Il33 and Myocardial Infarction
 Fibrosis Antibodies  >6 publications with Il33 and Fibrosis
 Neoplasms Antibodies  >5 publications with Il33 and Neoplasms
 Heart Failure Antibodies  >5 publications with Il33 and Heart Failure
 Dermatitis, Atopic Antibodies  >4 publications with Il33 and Dermatitis, Atopic

Organs/Tissues associated with anti-Il33 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >14 publications with Il33 and Lung
 Muscle Antibodies  >8 publications with Il33 and Muscle
 Skin Antibodies  >8 publications with Il33 and Skin
 Bone Antibodies  >5 publications with Il33 and Bone
 Lymph Node Antibodies  >3 publications with Il33 and Lymph Node
 Eye Antibodies  >3 publications with Il33 and Eye
 Connective Tissue Antibodies  >3 publications with Il33 and Connective Tissue
 Kidney Antibodies  >2 publications with Il33 and Kidney
 Spleen Antibodies  >2 publications with Il33 and Spleen
 Pancreas Antibodies  >2 publications with Il33 and Pancreas
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