Deleted in Azoospermia-Associated Protein 1 (DAZAP1) Antibody – Mouse Monoclonal

In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq]

DAZAP1: a ubiquitous RNA-binding protein highly expressed in the human and the mouse testes. In round spermatids, it localizes mainly in the nuclei, whereas in elongated spermatids, it localizes to the cytoplasm. Expressed at lower level in thymus and weakly expressed in heart, liver, brain, placenta, lung, skeletal muscle, kidney and pancreas. Fusion proteins between DAZAP1 and MEF2D have been observed in the TS-2 acute lymphoblastic leukemia (ALL) cell line. Two alternatively spliced isoforms have been described.

Protein type: RNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: RNA binding; nucleotide binding

Biological Process: positive regulation of nuclear mRNA splicing, via spliceosome; cell proliferation; spermatogenesis; cell differentiation; maternal placenta development