Syntrophin (SNTG2) Antibody – Mouse Monoclonal

The syntrophins are a family of scaffolding proteins with multiple protein interaction domains that link signaling proteins to dystrophin family members. Each of the three most characterized syntrophins (alpha, beta-1, and beta-2) contains a PDZ domain that binds a unique set of signaling proteins including kinases, ion and water channels, and neuronal nitric oxide synthase (nNOS). Despite their ability to bind dystrophin in vitro, neither -syntrophin isoform co-localizes with dystrophin in skeletal muscle. Furthermore, -syntrophins do not co-purify with dystrophin isolated from mouse tissue. Research suggests that the interaction of -syntrophin with dystrophin is transient and potentially subject to regulatory mechanisms. 1-Syntrophin is highly expressed in brain and is specifically localized in hippocampal pyramidal neurons, Purkinje neurons in cerebellum, and cortical neurons. 2-Syntrophin is expressed in many tissues including skeletal muscle where it is found only in the subsynaptic space beneath the neuromuscular junction. In both neurons and muscle, -syntrophin isoforms localize to the endoplasmic reticulum where they may form a scaffold for signaling and trafficking (Adams, 2006).

Small volumes of anti-SNTG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS607629 is an antibody targeting SNTG2. Also known as Syntrophin (dystrophin-associated protein A1, 59kD, basic component 1, 59-DAP, 59kD dystrophin-associated protein A1 basic component 1, A1B, Beta-1-syntrophin, BSYN2, DAPA1B, FLJ22442, MGC111389, SNT2, SNT2B1, Syntrophin-2, Tax interaction protein 43, TIP. Reactive in Human, Mouse, Rabbit, Rat. Host: Mouse.