Phosphoinositide 3 Kinase, P85 Beta (PIK3R2) Antibody – Mouse Monoclonal

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012]

PIK3R2: regulatory subunit of phosphoinositide-3-kinase. Mediates binding to a subset of tyrosine-phosphorylated proteins through its SH2 domain. Acts as an adapter, mediating the association of the p110 catalytic unit of the alpha, beta and delta enzymes to the plasma membrane, where p110 phosphorylates inositol lipids. May play an additional role in the regulation of the actin cytoskeleton. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Its SH2 domains interacts with the YTHM motif of phosphorylated INSR in vitro. Defects in PIK3R1 are a cause of severe insulin resistance. Four alternatively spliced isoforms have been described.

Protein type: Kinase, lipid; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19q13.2-q13.4

Cellular Component: phosphoinositide 3-kinase complex; nucleus; cytosol

Molecular Function: protein binding; protein heterodimerization activity; 1-phosphatidylinositol-3-kinase activity; phosphoinositide 3-kinase regulator activity; receptor tyrosine kinase binding; protein phosphatase binding

Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide 3-kinase cascade; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; T cell receptor signaling pathway; regulation of phosphoinositide 3-kinase activity; regulation of small GTPase mediated signal transduction; protein transport; cellular response to insulin stimulus; phospholipid metabolic process; small GTPase mediated signal transduction; insulin receptor signaling pathway; phosphatidylinositol biosynthetic process; positive regulation of transcription factor import into nucleus; cell glucose homeostasis; innate immune response; positive regulation of transcription from RNA polymerase II promoter; regulation of autophagy; blood coagulation; vascular endothelial growth factor receptor signaling pathway; leukocyte migration

Disease: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus Syndrome 1