CD16 Antibody – Rat Monoclonal

The lymphocyte Fc-gamma receptors recognize the Fc portion of IgG, presented either as immune complexes or as free antibody. The different classes of receptors are distinct because of varying size, tissue distribution and affinity for IgGs. The Fc type II receptor is expressed on a wide variety of cells including B cells, hematopoietic cells, monocyte/macrophages, neutrophils, platelets, Langerhans cells, eosinophils, basophils, trophoblasts, and endothelial cells of the placenta.1, 2 The Fc-g type III receptors are higher affinity than the type II and are expressed on macrophages, NK cells and neutrophils. Both types of receptors can be expressed on the same cell and in varying ratios.1 The receptors are constitutively expressed, although cytokines and lymphokines can modulate their expression.4 Besides identifying Fc-gammaR+ cells, monoclonal antibodies to the Fc-gII/III receptor have been used to block Fc receptor binding of IgG, Fc-mediated signal transduction and effector functions, clearance of immune complexes and to attenuate infection by organisms dependent on Fc-gR for parasitic invasion.4-6

Small volumes of anti-CD16,32 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS607887 is an antibody targeting CD16,32. Also known as CD16,32 (Azide Free). Reactive in Mouse. Host: Rat.