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STRN3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS608115

SG2NA, also known as Striatin 3, was identified as a human cancer auto-antigen and has not been implicated in vesicular trafficking and signal tranduction. It is highly related to striatin and zinedin (striatin 4). It is a cytoplasmic scaffolding protein that… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SG2NA (STRN3), Monoclonal Antibody
Full Product Name
SG2NA (Striatin-3, calmodulin binding protein 3, Cell-cycle autoantigen SG2NA, GS2NA, S/G2 Antigen)
Product Gene Name
anti-STRN3 antibody
Product Synonym Names
Anti -SG2NA (Striatin-3, calmodulin binding protein 3, Cell-cycle autoantigen SG2NA, GS2NA, S/G2 Antigen)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
9H272
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in 0.02% sodium azide, 40% glycerol.
Purity/Purification
Ascites
Ascites
Specificity
Recognizes SG2NA at 93kD. Does not crossreact with striatin. Species Crossreactivity: human, rat, mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Molecular Weight
87,209 Da
Chromosome Location
Chromosome: 14; NC_000014.8 (31362985..31495607, complement). Location: 14q13-q21
OMIM
614766
3D Structure
ModBase 3D Structure for Q13033
Immunogen
Synthetic peptide from SG2NA. Cellular Localization: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).
Positive Control
L6 cell lysate

Product Categories/Family for anti-STRN3 antibody

Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-STRN3 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)
Application Notes for anti-STRN3 antibody
Suitable for use in Western Blot, Immunoprecipitation and Immunocytochemistry.
Dilution: Western Blot: 1:1000 detected SG2NA on 10ug of L6 lysates. Recgonizes SG2NA at ~93kD in Jurkat cell lysate. In some cell types, a band of ~70kD is also recognized, which may be an alternatively splliced form of SG2NA or another unknown protein.
Immunoprecipitation: 3ul
Immunocytochemistry: 1:500

Testing Data of anti-STRN3 antibody

L6 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with MBS608115 (1:500 dilution). |Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates protein SG2NA (~93kD).
Mouse Anti-STRN3 Monoclonal Antibody – Cat# MBS608115

Testing Data of anti-STRN3 antibody

RAW 264 lysate (Lane1), NIH/3T3 lysate (Lane 2), C2C12 lysate (Lane 3), PC12 lysate (Lane 4), L6 lysate (Lane 5) and HepG2 lysate (Lane 6) were resolved by electrophoresis, transferred to PVDF membrane and probed with MBS608115 (1:500). Proteins were visualized using a Gt xMo IgG (HRP) and a chemiluminescence detection system. Arrow indicates protein SG2NA (~93kD).
Mouse Anti-STRN3 Monoclonal Antibody, Testing Data – Cat# MBS608115

Other Notes

Small volumes of anti-STRN3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STRN3 purchase

MBS608115 is an antibody targeting STRN3. Also known as SG2NA (Striatin-3, calmodulin binding protein 3, Cell-cycle autoantigen SG2NA, GS2NA, S/G2 Antigen). Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for STRN3. It may not necessarily be applicable to this product.

NCBI GI #
142976686
NCBI GeneID
29966
NCBI Accession #
NP_001077362.1
UniProt Primary Accession #
Q13033
UniProt Secondary Accession #
Q9NRA5; A2RTX7; A6NHZ7
UniProt Related Accession #
Q13033
GenBank Nucleotide #
NM_001083893.1
NCBI Official Full Name
striatin-3 isoform 1
NCBI Official Synonym Full Names
striatin, calmodulin binding protein 3
NCBI Official Symbol
STRN3
NCBI Official Synonym Symbols
SG2NA
UniProt Protein Name
Striatin-3
UniProt Synonym Protein Names
Cell cycle autoantigen SG2NA; S/G2 antigen
Protein Family
Striatin
UniProt Gene Name
STRN3
UniProt Synonym Gene Names
GS2NA; SG2NA
UniProt Entry Name
STRN3_HUMAN
NCBI Protein Information
striatin-3; s/G2 antigen; nuclear autoantigen; cell cycle autoantigen SG2NA; cell cycle S/G2 nuclear autoantigen

UniProt Comments for STRN3

SG2NA: a protein of the WD-repeat striatin family. Mainly expressed within neurons and thought to act both as scaffolds and as Ca(2+)-dependent signalling proteins. May interact with protein phosphatase 2A. Two alternatively spliced isoforms have been described.

Protein type: Transcription factor; Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q13-q21

Cellular Component: nucleoplasm; Golgi apparatus; protein phosphatase type 2A complex; protein complex; cell soma; dendrite; cytoplasm; plasma membrane; nucleus

Molecular Function: calmodulin binding; protein binding; protein phosphatase 2A binding; protein complex binding; transcription factor activity

Biological Process: positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; response to estradiol stimulus; negative regulation of estrogen receptor signaling pathway
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STRN3 antibody

 Reference Product  PubMed Publications
 PPP2CA antibody  >4 publications with STRN3 and PPP2CA

Diseases associated with anti-STRN3 antibody

 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >1 publications with STRN3 and Lung Diseases
 Urinary Bladder Neoplasms Antibodies  >1 publications with STRN3 and Urinary Bladder Neoplasms

Organs/Tissues associated with anti-STRN3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with STRN3 and Brain
 Muscle Antibodies  >2 publications with STRN3 and Muscle
 Lung Antibodies  >1 publications with STRN3 and Lung
 Uterus Antibodies  >1 publications with STRN3 and Uterus
 Embryonic Tissue Antibodies  >1 publications with STRN3 and Embryonic Tissue
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