Mouse Anti-NELL1 Monoclonal Antibody – Cat# MBS608144

Western blot detection of NEL-like protein 1 expression in transfected 293T cell lysate. Lane 1: NEL-like protein 1 transfected 293T lysate. Lane 2: Non-transfected 293T lysate.

NEL-Like Protein 1 (NELL1) Antibody – Mouse Monoclonal

Name: NELL1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS608144
Price: 750 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS608144

NEL-like protein 1 is a secreted protein that contains 6 epidermal growth factor (EGF)-like domains. The homotrimer may be involved in the control of cell growth and differentiation. HEL-like protein 1 is expressed in craniofacial anomalies. More details

$750 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NEL-like protein 1 (Nell1), Monoclonal Antibody

Full Product Name

NEL-like protein 1 (Protein kinase C-binding protein NELL1, Nel-related protein 1, NELL1, NRP1)

Product Gene Name

anti-Nell1 antibody

Product Synonym Names

Anti -NEL-like protein 1 (Protein kinase C-binding protein NELL1, Nel-related protein 1, NELL1, NRP1)

Clonality

Monoclonal

Isotype

IgG

Clone Number

9G387

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a lyophilized powder in PBS, pH 7.2. Reconstitute with 100ul sterile ddH2O.

Purity/Purification

Affinity Purified
Purified by affinity chromatography.

Specificity

Recognizes human NEL-like protein 1.

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20 degree C. Aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

89,212 Da

Chromosome Location

Chromosome: 1; NC_005100.3 (106397933..107260905). Location: 1q22

3D Structure

ModBase 3D Structure for Q62919

Immunogen

Partial recombinant human NEL-like protein 1 (304-404) with a GST tag.

Product Categories/Family for anti-Nell1 antibody

Antibodies; Abs to Protein Kinases

Applications Tested/Suitable for anti-Nell1 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-Nell1 antibody

Suitable for use in Western Blot and ELISA.

Other Notes

Small volumes of anti-Nell1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nell1 purchase

MBS608144 is an antibody targeting Nell1. Also known as NEL-like protein 1 (Protein kinase C-binding protein NELL1, Nel-related protein 1, NELL1, NRP1). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Nell1. It may not necessarily be applicable to this product.

NCBI GI #

149055783

NCBI GeneID

81733

NCBI Accession #

EDM07214.1

UniProt Primary Accession #

Q62919

UniProt Related Accession #

Q62919

NCBI Official Full Name

NEL-like 1 (chicken), isoform CRA_b

NCBI Official Synonym Full Names

NEL-like 1 (chicken)

NCBI Official Symbol

Nell1

UniProt Protein Name

Protein kinase C-binding protein NELL1

UniProt Synonym Protein Names

NEL-like protein 1

Protein Family

Protein kinase C-binding protein

UniProt Gene Name

Nell1

UniProt Entry Name

NELL1_RAT

NCBI Protein Information

protein kinase C-binding protein NELL1; NEL-like protein 1

NCBI Summary for Nell1

interacts with and phosphorylated by protein kinase C betaI (PKCbetaI) and is involved in modulation of osteoblast differentiation; overexpression of human homolog is associated with craniosynostosis [RGD, Feb 2006]

UniProt Comments for Nell1

NELL1: Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space; perinuclear region of cytoplasm; cytoplasm; nuclear envelope

Molecular Function: heparin binding; identical protein binding; protein kinase C binding; calcium ion binding

Biological Process: positive regulation of osteoblast differentiation; regulation of osteoblast differentiation; positive regulation of apoptosis; regulation of gene expression; negative regulation of osteoblast proliferation; cell differentiation; positive regulation of bone mineralization; positive regulation of ossification

Research Articles on Nell1

1. Thus, NELL-1 effectively enhances in situ osteogenesis in the bone marrow, making it potentially useful in the prevention and treatment of osteoporotic fractures.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Nell1 antibody

Reference Product	PubMed Publications
Runx2 antibody	>14 publications with Nell1 and Runx2

Diseases associated with anti-Nell1 antibody

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>10 publications with Nell1 and Congenital Abnormalities
Craniosynostoses Antibodies	>7 publications with Nell1 and Craniosynostoses
Intestinal Neoplasms Antibodies	>2 publications with Nell1 and Intestinal Neoplasms
Disease Models, Animal Antibodies	>2 publications with Nell1 and Disease Models, Animal
Nerve Degeneration Antibodies	>1 publications with Nell1 and Nerve Degeneration
Abnormalities, Multiple Antibodies	>1 publications with Nell1 and Abnormalities, Multiple
Carcinoma, Hepatocellular Antibodies	>1 publications with Nell1 and Carcinoma, Hepatocellular
Motor Skills Disorders Antibodies	>1 publications with Nell1 and Motor Skills Disorders
Rhabdomyosarcoma Antibodies	>1 publications with Nell1 and Rhabdomyosarcoma

Organs/Tissues associated with anti-Nell1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>7 publications with Nell1 and Brain
Pancreas Antibodies	>1 publications with Nell1 and Pancreas