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TRPM2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS608280

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround… More details

$815 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
TRPM2, Monoclonal Antibody
Full Product Name
TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2, Estrogen Responsive Element Associated Gene 1, Estrogen-responsive Element-associated Gene 1 Protein, EREG1, KNP3, Long Transient Receptor Potential Channel 2, LTRPC 2, LTRPC2, LTRPC
Product Gene Name
anti-TRPM2 antibody
Product Synonym Names
Anti -TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2, Estrogen Responsive Element Associated Gene 1, Estrogen-responsive Element-associated Gene 1 Protein, EREG1, KNP3, Long Transient Receptor Potential Channel 2, LTRPC 2, LTRPC2, LTRPC
Clonality
Monoclonal
Isotype
IgG1
Clone Number
10F775
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH7.4, 0.09% sodium azide, 50% glycerol.
Purity/Purification
Purified by Protein G affinity chromatography.
Concentration
1 mg/ml (lot specific)
Specificity
Recognizes human TrpC7. Species Crossreactivity: Mouse and Rat.
Preparation and Storage
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Chromosome Location
Chromosome: 21; NC_000021.8 (45773484..45862964). Location: 21q22.3
OMIM
603749
3D Structure
ModBase 3D Structure for Q9HCX4
Immunogen
Synthetic peptide corresponding to aa 845-862 of human TRPC7. Cellular Location: membrane
Grade
Affinity Purified

Product Categories/Family for anti-TRPM2 antibody

Antibodies; Abs to Receptors; Estrogen
Applications Tested/Suitable for anti-TRPM2 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (IHC)
Other applications not yet tested.
Application Notes for anti-TRPM2 antibody
Recommended Dilution:

Western Blot: 1:1000. 1ug/ml detects TrpC7 in 10ug of rat brain lyste using goat anti-mouse IgG (HRP) as secondary antibody.
Immunohistochemistry: 1:1000
Immunofluorescence: 1:100

Optimal dilutions to be determined by the researcher.

Other Notes

Small volumes of anti-TRPM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRPM2 purchase

MBS608280 is an antibody targeting TRPM2. Also known as TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2, Estrogen Responsive Element Associated Gene 1, Estrogen-responsive Element-associated Gene 1 Protein, EREG1, KNP3, Long Transient Receptor Potential Channel 2, LTRPC 2, LTRPC2, LTRPC. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TRPM2. It may not necessarily be applicable to this product.

NCBI GI #
4507689
NCBI GeneID
7226
NCBI Accession #
NP_003298.1
UniProt Primary Accession #
Q9HCX4
UniProt Secondary Accession #
Q5KTC2; Q6J3P5; Q96KN6; Q96Q93; D3DSL6
UniProt Related Accession #
O94759; Q14DR2; Q5KTC1
GenBank Nucleotide #
NM_003307.3
NCBI Official Full Name
transient receptor potential cation channel subfamily M member 2
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily M, member 2
NCBI Official Symbol
TRPM2
NCBI Official Synonym Symbols
KNP3; EREG1; TRPC7; LTRPC2; NUDT9H; NUDT9L1; MGC133383
UniProt Protein Name
Transient receptor potential cation channel subfamily M member 2
UniProt Synonym Protein Names
Estrogen-responsive element-associated gene 1 protein; Long transient receptor potential channel 2; LTrpC-2; LTrpC2; Transient receptor potential channel 7
Protein Family
Transient receptor potential cation channel subfamily
UniProt Gene Name
TRPM2
UniProt Synonym Gene Names
EREG1; KNP3; LTRPC2; TRPC7
UniProt Entry Name
TRPM2_HUMAN
NCBI Protein Information
transient receptor potential cation channel subfamily M member 2; LTrpC-2; OTTHUMP00000038504; OTTHUMP00000038505; OTTHUMP00000109530; OTTHUMP00000207883; transient receptor potential channel 7; long transient receptor potential channel 2; estrogen-responsive element-associated gene 1 protein

NCBI Summary for TRPM2

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq]
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UniProt Comments for TRPM2

TRPM2: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.1.13; Membrane protein, multi-pass; Membrane protein, integral; Hydrolase; Transporter; Channel, calcium

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: ADP-ribose diphosphatase activity; calcium channel activity; manganese ion transmembrane transporter activity; sodium channel activity

Biological Process: response to hydroperoxide; metabolic process; calcium ion transport; transmembrane transport
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Research Articles on TRPM2

1. Our findings suggest that the elevation of [Na(+)](in) and [Ca(2+)](in) induced ONP apoptosis and altered the expression of TRPM2. Lithium pretreatment attenuated the apoptosis induced by ionic stress.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TRPM2 antibody

 Reference Product  PubMed Publications
 TRPC6 antibody  >28 publications with TRPM2 and TRPC6

Diseases associated with anti-TRPM2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >381 publications with TRPM2 and Neoplasms
 Neurodegenerative Diseases Antibodies  >123 publications with TRPM2 and Neurodegenerative Diseases
 Cardiovascular Diseases Antibodies  >97 publications with TRPM2 and Cardiovascular Diseases
 Inflammation Antibodies  >92 publications with TRPM2 and Inflammation
 Necrosis Antibodies  >85 publications with TRPM2 and Necrosis
 Breast Neoplasms Antibodies  >59 publications with TRPM2 and Breast Neoplasms
 Endocrine Gland Neoplasms Antibodies  >36 publications with TRPM2 and Endocrine Gland Neoplasms
 Urologic Neoplasms Antibodies  >33 publications with TRPM2 and Urologic Neoplasms
 Liver Diseases Antibodies  >27 publications with TRPM2 and Liver Diseases
 Neoplasm Metastasis Antibodies  >27 publications with TRPM2 and Neoplasm Metastasis

Organs/Tissues associated with anti-TRPM2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >367 publications with TRPM2 and Blood
 Brain Antibodies  >251 publications with TRPM2 and Brain
 Prostate Antibodies  >218 publications with TRPM2 and Prostate
 Testis Antibodies  >144 publications with TRPM2 and Testis
 Nerve Antibodies  >117 publications with TRPM2 and Nerve
 Eye Antibodies  >69 publications with TRPM2 and Eye
 Lung Antibodies  >56 publications with TRPM2 and Lung
 Embryonic Tissue Antibodies  >48 publications with TRPM2 and Embryonic Tissue
 Epididymis Antibodies  >48 publications with TRPM2 and Epididymis
 Pancreas Antibodies  >42 publications with TRPM2 and Pancreas
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