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KLRK1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS608514

CD314 is also known as natural killer receptor G2 (NKG2D) and as killer cell lectin-like receptor subfamily K, member 1 (KLRK1). CD314 is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, CD8 T cells and gamma… More details

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Product Overview

Online Datasheet in PDF
Product Name
KLRK1, Monoclonal Antibody
Full Product Name
KLRK1 (Killer Cell Lectin-like Receptor Subfamily K Member 1, CD314, HGNC:18788, D12S2489E, NK Cell Receptor D, NK Lectin-like Receptor, NKLLR, NKG2D Activating NK Receptor, NKG2D Type II Integral Membrane Protein, NKR P2)
Product Gene Name
anti-Klrk1 antibody
Product Synonym Names
Anti -KLRK1 (Killer Cell Lectin-like Receptor Subfamily K Member 1, CD314, HGNC:18788, D12S2489E, NK Cell Receptor D, NK Lectin-like Receptor, NKLLR, NKG2D Activating NK Receptor, NKG2D Type II Integral Membrane Protein, NKR P2)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
10B1387
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human KLRK1. Reported to inhibit T cell recognition of MICA (1, 6).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
26,710 Da
Chromosome Location
Chromosome: 6; NC_000072.5 (129560339..129573859, complement). Location: 6 F3; 6 62.53 cM
3D Structure
ModBase 3D Structure for Q4FJM0
Immunogen
NKL cells

Product Categories/Family for anti-Klrk1 antibody

Antibodies; Abs to Cell Markers
Applications Tested/Suitable for anti-Klrk1 antibody
Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-Klrk1 antibody
Suitable for use in Flow Cytometry, Immunohistochemistry and Immunoprecipitation.
Dilution: Flow Cytometry: 1:100; 10ul labels 10e6 cells in 100ul
Immunohistochemistry: Frozen sections

Immunohistochemistry (IHC) of anti-Klrk1 antibody

Immunohistochemistry analysis of human tonsil cryosection using MBS608514.
Mouse Anti-KLRK1 Monoclonal Antibody – Cat# MBS608514

Immunohistochemistry (IHC) of anti-Klrk1 antibody

Immunohistochemistry analysis of human spleen cryosection using MBS608514.
Mouse Anti-KLRK1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS608514

Immunohistochemistry (IHC) of anti-Klrk1 antibody

Immunohistochemistry analysis of human spleen cryosection using MBS608514.
Mouse Anti-KLRK1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS608514

Immunohistochemistry (IHC) of anti-Klrk1 antibody

Immunohistochemistry analysis of human tonsil cryosection using MBS608514.
Mouse Anti-KLRK1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS608514

Flow Cytometry (FC/FACS) of anti-Klrk1 antibody

Figure A: Flow Cytometry analysis of red cell lysed human peripheral blood using C2259-14J CD8 (FITC) and Alexa647® conjugated Mouse IgG1 isotype control|Figure B. Flow Cytometry analysis of red cell lysed human peripheral blood using C2259-14J CD8 (FITC) and Alexa647® conjugatedMBS608514.).
Mouse Anti-KLRK1 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS608514

Other Notes

Small volumes of anti-Klrk1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Klrk1 purchase

MBS608514 is an antibody targeting Klrk1. Also known as KLRK1 (Killer Cell Lectin-like Receptor Subfamily K Member 1, CD314, HGNC:18788, D12S2489E, NK Cell Receptor D, NK Lectin-like Receptor, NKLLR, NKG2D Activating NK Receptor, NKG2D Type II Integral Membrane Protein, NKR P2). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Klrk1. It may not necessarily be applicable to this product.

NCBI GI #
71060095
NCBI GeneID
27007
UniProt Primary Accession #
Q4FJM0
UniProt Related Accession #
O54709; Q2TJJ6; Q3TCW7; Q4FJM0
NCBI Official Full Name
Klrk1
NCBI Official Synonym Full Names
killer cell lectin-like receptor subfamily K, member 1
NCBI Official Symbol
Klrk1
NCBI Official Synonym Symbols
Nkg2d; NKG2-D; D6H12S2489E
UniProt Protein Name
Klrk1 protein
UniProt Synonym Protein Names
NKG2-D-activating NK receptor; NK cell receptor D; Killer cell lectin-like receptor subfamily K member 1
Protein Family
NKG2-D type II integral membrane protein
UniProt Gene Name
Klrk1
UniProt Synonym Gene Names
Nkg2d
UniProt Entry Name
Q4FJM0_MOUSE
NCBI Protein Information
NKG2-D type II integral membrane protein; NK cell receptor D; natural killer cell group 2D; NKG2-D-activating NK receptor

UniProt Comments for Klrk1

KLRK1: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface; Receptor, misc.

Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: MHC class Ib receptor activity; protein binding; protein homodimerization activity; MHC class I protein binding; carbohydrate binding; kinase binding

Biological Process: stimulatory C-type lectin receptor signaling pathway; positive regulation of interferon-gamma production; defense response to Gram-positive bacterium; positive regulation of nitric oxide biosynthetic process; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; immune system process; positive regulation of apoptosis; innate immune response; natural killer cell activation; cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of myeloid dendritic cell activation
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Research Articles on Klrk1

1. Expression of RAE-1 proteins on erythroblast surfaces increased early after Friend virus inoculation and infected erythroid cells are recognized by natural killer cells mainly through the NKG2D-RAE-1 interactions in vivo.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Klrk1 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram

Diseases associated with anti-Klrk1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >218 publications with Klrk1 and Neoplasms
 Leukemia Antibodies  >34 publications with Klrk1 and Leukemia
 Female Urogenital Diseases Antibodies  >26 publications with Klrk1 and Female Urogenital Diseases
 Liver Diseases Antibodies  >25 publications with Klrk1 and Liver Diseases
 Melanoma Antibodies  >22 publications with Klrk1 and Melanoma
 Lymphoma Antibodies  >20 publications with Klrk1 and Lymphoma
 Inflammation Antibodies  >19 publications with Klrk1 and Inflammation
 Adenocarcinoma Antibodies  >17 publications with Klrk1 and Adenocarcinoma
 Skin Diseases Antibodies  >15 publications with Klrk1 and Skin Diseases
 Leukemia, Myeloid Antibodies  >14 publications with Klrk1 and Leukemia, Myeloid

Organs/Tissues associated with anti-Klrk1 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >20 publications with Klrk1 and Skin
 Spleen Antibodies  >16 publications with Klrk1 and Spleen
 Thymus Antibodies  >3 publications with Klrk1 and Thymus
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