Mouse Anti-DLG2 Monoclonal Antibody – Cat# MBS608610

Chapsyn 110 (DLG2) Antibody – Mouse Monoclonal

Name: DLG2 Antibody; Monoclonal; Mouse; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS608610
Price: 665 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS608610

Chapsyn-110, is a part of the membrane-associated putative guanylate kinase (MAGUK) family. It binds directly to the NMDA receptor, and Shaker K+ channel subunits, and is 70-80% identical to PSD-95/SAP90 and SAP97 (1). It associated tightly with the… More details

$665 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Chapsyn 110 (Dlg2), Monoclonal Antibody

Full Product Name

Chapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of SynapsesChapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of Synapses)

Product Gene Name

anti-Dlg2 antibody

Product Synonym Names

Anti -Chapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of SynapsesChapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of Synapses)

Clonality

Monoclonal

Isotype

IgG1

Clone Number

10F694

Host

Mouse

Species Reactivity

Human, Mouse, Rat

Form/Format

Supplied as a liquid in PBS, pH7.4, 50% glycerol and 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein G affinity chromatography.

Specificity

Recognizes rat Chapsyn-110. Species Crossreactivity: human (weak). No cross-reactivity against other.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

94,880 Da

Chromosome Location

Chromosome: 7; NC_000073.6 (91090786..92449246). Location: 7 E1; 7 51.07 cM

3D Structure

ModBase 3D Structure for Q91XM9

Immunogen

Fusion protein aa 1-852 of rat Chapsyn-110 (accession number Q63622).

Product Categories/Family for anti-Dlg2 antibody

Antibodies; Abs to PDZ Domain

Applications Tested/Suitable for anti-Dlg2 antibody

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

Application Notes for anti-Dlg2 antibody

Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry.
Dilution: Western Blot:1-10ug/ml
Immunohistochemistry:0.1-1ug/ml

Other Notes

Small volumes of anti-Dlg2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Dlg2 purchase

MBS608610 is an antibody targeting Dlg2. Also known as Chapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of SynapsesChapsyn 110 (PSD93, Discs Large Homolog 2, DLG2, Channel-associated Protein of Synapses). Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Dlg2. It may not necessarily be applicable to this product.

NCBI GI #

3335543

NCBI GeneID

23859

NCBI Accession #

AAC27299.1

UniProt Primary Accession #

Q91XM9

UniProt Secondary Accession #

Q8BXK7; Q8BYG5; F8VQM7

UniProt Related Accession #

Q91XM9

NCBI Official Full Name

chapsyn-110

NCBI Official Synonym Full Names

discs, large homolog 2 (Drosophila)

NCBI Official Symbol

Dlg2

NCBI Official Synonym Symbols

Dlgh2; PSD93; Gm1197; A330103J02Rik; B230218P12Rik; B330007M19Rik

UniProt Protein Name

Disks large homolog 2

UniProt Synonym Protein Names

Channel-associated protein of synapse-110; Chapsyn-110; Postsynaptic density protein PSD-93

Protein Family

Disks large

UniProt Gene Name

Dlg2

UniProt Synonym Gene Names

Dlgh2; Chapsyn-110

UniProt Entry Name

DLG2_MOUSE

NCBI Protein Information

disks large homolog 2; chapsyn-110; postsynaptic density protein PSD-93; channel-associated protein of synapse-110

UniProt Comments for Dlg2

PSD-93: Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. Interacts through its PDZ domains with NETO1. Interacts with NOS1/nNOS through second PDZ domain. Interacts with KCNJ2/Kir2.1 (via C-terminus) through one of its PDZ domains. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Interacts with FASLG. Belongs to the MAGUK family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; cell projection; membrane; cell soma; cytoplasm; dendrite; plasma membrane; ionotropic glutamate receptor complex; synapse; cell junction

Molecular Function: protein C-terminus binding; guanylate kinase activity; ionotropic glutamate receptor binding; protein binding; protein heterodimerization activity; protein phosphatase binding; kinase binding; PDZ domain binding

Biological Process: nervous system development; synaptic transmission; neuronal ion channel clustering; sensory perception of pain; receptor clustering; nucleotide phosphorylation

Research Articles on Dlg2

1. Membrane-associated guanylate kinase homolog PSD-93 is a central organizer of the postsynaptic density at excitatory synapses on pyramidal neurons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Dlg2 antibody

Products by Pathway	Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
Wnt Signaling Pathway NetPath antibodies	Wnt Signaling Pathway NetPath Diagram

Diseases associated with anti-Dlg2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>4 publications with Dlg2 and Neoplasms
Ovarian Neoplasms Antibodies	>2 publications with Dlg2 and Ovarian Neoplasms
Ovarian Diseases Antibodies	>2 publications with Dlg2 and Ovarian Diseases
Breast Neoplasms Antibodies	>2 publications with Dlg2 and Breast Neoplasms
Gonadal Disorders Antibodies	>2 publications with Dlg2 and Gonadal Disorders
Nervous System Diseases Antibodies	>2 publications with Dlg2 and Nervous System Diseases
Cognition Disorders Antibodies	>2 publications with Dlg2 and Cognition Disorders
Carcinoma Antibodies	>1 publications with Dlg2 and Carcinoma
Neoplasms, Experimental Antibodies	>1 publications with Dlg2 and Neoplasms, Experimental
Weight Loss Antibodies	>1 publications with Dlg2 and Weight Loss

Organs/Tissues associated with anti-Dlg2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>26 publications with Dlg2 and Brain
Embryonic Tissue Antibodies	>2 publications with Dlg2 and Embryonic Tissue
Lung Antibodies	>1 publications with Dlg2 and Lung
Spinal Cord Antibodies	>1 publications with Dlg2 and Spinal Cord
Skin Antibodies	>1 publications with Dlg2 and Skin