Neutrophils, Apoptotic Antibody – Mouse Monoclonal

Anti-Neutrophils, Apoptotic binds to the surface of apoptotic neutrophils. Neutrophils have been implicated in the pathogenenesis of a variety of inflammatory diseases including the adult respiratory distress syndrome, idiopathic pulmonary fibrosis, ulcerative colitis and rheumatoid arthritis. Although the neutrophil is a vital component of the body's defense against infectious agents, uncontrolled release of its toxic substances may inflict "friendly fire" damage on surrounding tissue and propagate the inflammatory response, leading to scarring and tissue destruction. Apoptosis leads to recognition and safe disposal of dying cells by phagocytosis. Binding of the monoclonal antibody to apoptotic neutrophils is dependent on the presence of sialoglycoprotein fetuin, a constituent of bovine serum. Fetuin is the antigen for this monoclonal antibody, and together form a complex in solution that is necessary and sufficient for binding to apoptotic neutrophils. The antigen recognized may act as a "molecular bridge" between the surface of the apoptotic neutrophil and the phagocyte to modulate apoptotic neutrophil clearance at inflammatory sites. Human macrophage phagocytosis of apoptotic neutrophils was augmented in vitro by addition of the antigen recognized, which does not bind to other apoptotic leukocytes.

Small volumes of anti-Neutrophils, Apoptotic antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS608691 is an antibody targeting Neutrophils, Apoptotic. Also known as Neutrophils, Apoptotic (FITC). Reactive in Human. Host: Mouse.