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MONOCYTE, Macrophage MARKER (CD14) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS608909

CD14 is a glycophosphatidylinositol-linked protein, which is part of the LPS receptor complex. CD14 binds lipopolysaccharide (LPS) and as such, acts as a pattern recognition receptor (PRR). CD14 has also been suggested to mediate phagocytosis of bacteria an… More details

$1105 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CD14, MONOCYTE, MACROPHAGE MARKER, Monoclonal Antibody
Full Product Name
CD14, MONOCYTE, MACROPHAGE MARKER
Product Gene Name
anti-CD14 antibody
Product Synonym Names
Anti -CD14, MONOCYTE, MACROPHAGE MARKER
Clonality
Monoclonal
Isotype
IgG1
Clone Number
9G141
Host
Mouse
Species Reactivity
Human, Porcine
Form/Format
Supplied as a liquid in PBS, 0.1% BSA.
Purity/Purification
Affinity Purified
Purified
Specificity
Recognizes human monocyte marker CD14, a 53kD glycoprotein. Recognizes both soluble and membrane CD14. Useful for inhibition of biological activity of sCD14, also inhibits LPS induced TNF production. Species crossreactivity: Porcine.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
39,667 Da
Chromosome Location
Chromosome: 7; NC_007305.4 (51051080..51052496, complement)
3D Structure
ModBase 3D Structure for Q95122
Immunogen
Human sCD14.

Product Categories/Family for anti-CD14 antibody

Antibodies; Abs to CD Markers
Applications Tested/Suitable for anti-CD14 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CD14 antibody
Suitable for use in Flow Cytometry, and for inhibition of biological activity of sCD14.
Dilution: Flow Cytometry: 1:50

Other Notes

Small volumes of anti-CD14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD14 purchase

MBS608909 is an antibody targeting CD14. Also known as CD14, MONOCYTE, MACROPHAGE MARKER. Reactive in Human, Porcine. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CD14. It may not necessarily be applicable to this product.

NCBI GI #
2274810
NCBI GeneID
281048
UniProt Primary Accession #
Q95122
UniProt Secondary Accession #
Q9TVA7; A8DBS7
UniProt Related Accession #
Q1PBC8; Q95122
NCBI Official Full Name
CD14
NCBI Official Symbol
CD14
UniProt Protein Name
Monocyte differentiation antigen CD14
UniProt Synonym Protein Names
Myeloid cell-specific leucine-rich glycoprotein
Protein Family
Monocyte differentiation antigen
UniProt Gene Name
CD14
UniProt Entry Name
CD14_BOVIN
NCBI Protein Information
monocyte differentiation antigen CD14; CD14 antigen; myeloid cell-specific leucine-rich glycoprotein

UniProt Comments for CD14

Function: Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules

Subunit structure: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4

Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor

Sequence similarities: Contains 11 LRR (leucine-rich) repeats.
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Research Articles on CD14

1. This study study confirmed that expression of CD14 in blood polymorpnuclear cells (PMN), resident PMN and inflammatory PMN from heifer mammary glands was accompanied by apoptosis and necrosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD14 antibody

 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immunity Signaling Pathway antibodies  Innate Immunity Signaling Pathway Diagram
 LPS Transferred From LBP Carrier To CD14 Pathway antibodies  LPS Transferred From LBP Carrier To CD14 Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram

Diseases associated with anti-CD14 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1580 publications with CD14 and Inflammation
 Neoplasms Antibodies  >1255 publications with CD14 and Neoplasms
 Leukemia Antibodies  >802 publications with CD14 and Leukemia
 Leukemia, Myeloid Antibodies  >562 publications with CD14 and Leukemia, Myeloid
 Cardiovascular Diseases Antibodies  >433 publications with CD14 and Cardiovascular Diseases
 Autoimmune Diseases Antibodies  >424 publications with CD14 and Autoimmune Diseases
 Lung Diseases Antibodies  >421 publications with CD14 and Lung Diseases
 Arthritis, Rheumatoid Antibodies  >246 publications with CD14 and Arthritis, Rheumatoid
 Liver Diseases Antibodies  >244 publications with CD14 and Liver Diseases
 Lymphoma Antibodies  >211 publications with CD14 and Lymphoma

Organs/Tissues associated with anti-CD14 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5965 publications with CD14 and Blood
 Liver Antibodies  >467 publications with CD14 and Liver
 Kidney Antibodies  >262 publications with CD14 and Kidney
 Muscle Antibodies  >215 publications with CD14 and Muscle
 Brain Antibodies  >213 publications with CD14 and Brain
 Intestine Antibodies  >164 publications with CD14 and Intestine
 Ovary Antibodies  >108 publications with CD14 and Ovary
 Uterus Antibodies  >103 publications with CD14 and Uterus
 Adipose Tissue Antibodies  >79 publications with CD14 and Adipose Tissue
 Reticulum Antibodies  >36 publications with CD14 and Reticulum
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