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PLXNB1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS608937

Plexin B1 is a 300kD member of the B subfamily, plexin family of semaphorin receptors. Mature human Plexin B1 is a 2116aa type I transmembrane (TM) glycoprotein that contains a 1471aa extracellular domain (ECD) and a 612aa cytoplasmic region. The ECD contains… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PLXNB1, Monoclonal Antibody
Full Product Name
PLXNB1 (Plexin B1, KIAA0407, MGC149167, PLXN5, Semaphorin Receptor SEP, SEP) (APC)
Product Gene Name
anti-PLXNB1 antibody
Product Synonym Names
Anti -PLXNB1 (Plexin B1, KIAA0407, MGC149167, PLXN5, Semaphorin Receptor SEP, SEP) (APC)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
10K23
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in 1ml saline, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human Plexin B1.
Preparation and Storage
May be stored at 4 degree C before opening. DO NOT FREEZE! Stable at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Freezing APC conjugates will result in a substantial loss of activity. APC conjugates are sensitive to light.
Molecular Weight
232,298 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (48445261..48471460, complement). Location: 3p21.31
OMIM
601053
3D Structure
ModBase 3D Structure for O43157
Immunogen
NS0 cells transfected with human Plexin B1 (aa1-2135; Accession #O43157, isoform 1).
Hybridoma
Fusion of a mouse myeloma with B cells obtained from a mouse immunized with NS0 cells transfected with human Plexin B1.

Product Categories/Family for anti-PLXNB1 antibody

Antibodies; Abs to Plexin; Semaphorin
Applications Tested/Suitable for anti-PLXNB1 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-PLXNB1 antibody
Suitable for use in Flow Cytometry.

Other Notes

Small volumes of anti-PLXNB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLXNB1 purchase

MBS608937 is an antibody targeting PLXNB1. Also known as PLXNB1 (Plexin B1, KIAA0407, MGC149167, PLXN5, Semaphorin Receptor SEP, SEP) (APC). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PLXNB1. It may not necessarily be applicable to this product.

NCBI GI #
194272180
NCBI GeneID
5364
NCBI Accession #
NP_001123554.1
UniProt Primary Accession #
O43157
UniProt Secondary Accession #
Q6NY20; Q9UIV7; Q9UJ92; Q9UJ93; A6H8Y2
UniProt Related Accession #
O43157
GenBank Nucleotide #
NM_001130082.1
NCBI Official Full Name
plexin-B1
NCBI Official Synonym Full Names
plexin B1
NCBI Official Symbol
PLXNB1
NCBI Official Synonym Symbols
SEP; PLXN5; KIAA0407; MGC149167; PLEXIN-B1
UniProt Protein Name
Plexin-B1
UniProt Synonym Protein Names
Semaphorin receptor SEP
Protein Family
Plexin
UniProt Gene Name
PLXNB1
UniProt Synonym Gene Names
KIAA0407; PLXN5; SEP
UniProt Entry Name
PLXB1_HUMAN
NCBI Protein Information
plexin-B1; plexin 5; OTTHUMP00000164806; OTTHUMP00000210032; OTTHUMP00000210033; semaphorin receptor SEP

UniProt Comments for PLXNB1

PLXNB1: Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Belongs to the plexin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: integral to plasma membrane; extracellular region; plasma membrane; intracellular

Molecular Function: protein binding; transmembrane receptor activity; semaphorin receptor activity; GTPase activating protein binding; receptor activity; semaphorin receptor binding

Biological Process: positive regulation of phosphoinositide 3-kinase cascade; regulation of cell shape; axon guidance; cell migration; positive regulation of axonogenesis; negative regulation of osteoblast proliferation; negative regulation of cell adhesion; signal transduction; neurite morphogenesis; regulation of cytoskeleton organization and biogenesis
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Research Articles on PLXNB1

1. plexin-B1, a target of miR-214, may function as an oncogene in human cervical cancer HeLa cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PLXNB1 antibody

 Reference Product  PubMed Publications
 SEMA4D antibody  >46 publications with PLXNB1 and SEMA4D
 MET antibody  >12 publications with PLXNB1 and MET
 PLXNA1 antibody  >10 publications with PLXNB1 and PLXNA1
 RAC1 antibody  >7 publications with PLXNB1 and RAC1
 RND1 antibody  >5 publications with PLXNB1 and RND1
 ARHGEF12 antibody  >3 publications with PLXNB1 and ARHGEF12
 ARHGEF11 antibody  >3 publications with PLXNB1 and ARHGEF11

Pathways associated with anti-PLXNB1 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Sema4D In Semaphorin Signaling Pathway antibodies  Sema4D In Semaphorin Signaling Pathway Diagram
 Sema4D Induced Cell Migration And Growth-cone Collapse Pathway antibodies  Sema4D Induced Cell Migration And Growth-cone Collapse Pathway Diagram
 Sema4D Mediated Inhibition Of Cell Attachment And Migration Pathway antibodies  Sema4D Mediated Inhibition Of Cell Attachment And Migration Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-PLXNB1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >20 publications with PLXNB1 and Neoplasms
 Neoplasm Metastasis Antibodies  >6 publications with PLXNB1 and Neoplasm Metastasis
 Leukemia Antibodies  >5 publications with PLXNB1 and Leukemia
 Breast Neoplasms Antibodies  >4 publications with PLXNB1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >3 publications with PLXNB1 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >2 publications with PLXNB1 and Cardiovascular Diseases
 Melanoma, Experimental Antibodies  >2 publications with PLXNB1 and Melanoma, Experimental
 Ovarian Neoplasms Antibodies  >2 publications with PLXNB1 and Ovarian Neoplasms
 Kidney Diseases Antibodies  >2 publications with PLXNB1 and Kidney Diseases
 Kidney Neoplasms Antibodies  >2 publications with PLXNB1 and Kidney Neoplasms

Organs/Tissues associated with anti-PLXNB1 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >87 publications with PLXNB1 and Nerve
 Embryonic Tissue Antibodies  >16 publications with PLXNB1 and Embryonic Tissue
 Brain Antibodies  >13 publications with PLXNB1 and Brain
 Kidney Antibodies  >9 publications with PLXNB1 and Kidney
 Vascular Antibodies  >7 publications with PLXNB1 and Vascular
 Bone Antibodies  >6 publications with PLXNB1 and Bone
 Lung Antibodies  >4 publications with PLXNB1 and Lung
 Uterus Antibodies  >4 publications with PLXNB1 and Uterus
 Lymph Node Antibodies  >4 publications with PLXNB1 and Lymph Node
 Ovary Antibodies  >3 publications with PLXNB1 and Ovary
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