SLC2A2 Antibody – Mouse Monoclonal

Most mammalian cells transport glucose through a family of membrane proteins known as glucose transporters. Molecular cloning of these glucose transporters has identified a family of closely related genes that encodes at least 7 proteins (Glut-1- Glut-14, Mol. Wt. 40-80kD) and Sodium glucose co-transporter- 1 (SGLT-1, 662aa; ~75kD). Individual member of this family have identical predicted secondary structures with 12 transmembrane domains. Both N and c-termini are predicted to be cytoplasmic. Most differences in sequence homology exist within the four hydrophilic domains that may play a role in tissue-specific targeting.

Human Glut-2 (GTR2, 524aa, chromosome 3q26.1-q26.3, ~60kD) belongs to the family of solute carrier family 2, member 2 or Slc2a2 or facilitative glucose transporter. Glut-2 likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. It is a multi-pass membrane protein. Primarily expressed in liver, insulin-producing beta cell, small intestine and kidney. Defects in SLC2A2 are the cause of Fanconi-Bickel syndrome (FBS, a rare, autosomal recessive mode and characterized by hepatorenal glycogen accumulation, and impaired utilization of glucose and galactose. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1).

Small volumes of anti-Slc2a2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS609281 is an antibody targeting Slc2a2. Also known as Anti-GLUT2 (Solute Carrier Family 2, Facilitated Glucose Transporter Member 2, Glucose Transporter Type 2, Liver, GLUT-2, SLC2A2). Reactive in Human. Host: Mouse.