Mouse Anti-SPTB Monoclonal Antibody – Cat# MBS609340

Spectrin, Beta, Erythrocytic (SPTB) Antibody – Mouse Monoclonal

Name: SPTB Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS609340
Price: 1165 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS609340

Erythroid spectrins, some other proteins of erythroid cytoskeleton, and the transmembrane protein band 3 are highly specific for erythrocytes and their progenitors. They are more reliable markers for erythroid differentiation than Glycophorin A, the commonly… More details

$1165 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Spectrin, beta, Erythrocytic (SPTB), Monoclonal Antibody

Full Product Name

Spectrin, beta, Erythrocytic (Erythroid beta-Spectrin, Spectrin beta Chain Erythrocyte, SPTB, Beta-I Spectrin, SPTB1, EL3, HS2, HSPTB1, SPH2)

Product Gene Name

anti-SPTB antibody

Product Synonym Names

Anti -Spectrin, beta, Erythrocytic (Erythroid beta-Spectrin, Spectrin beta Chain Erythrocyte, SPTB, Beta-I Spectrin, SPTB1, EL3, HS2, HSPTB1, SPH2)

Clonality

Monoclonal

Isotype

IgG1

Clone Number

DB2

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, 0.1 % sodium azide, 1% BSA.

Purity/Purification

Ascites
Serum

Specificity

Recognizes the 220kD human erythroid b-spectrin. Present in the membranes of human skeletal muscle cells.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

246,468 Da

Chromosome Location

Chromosome: 14; NC_000014.8 (65213001..65346604, complement). Location: 14q23-q24.2

OMIM

130600

3D Structure

ModBase 3D Structure for P11277

Immunogen

Ghost proteins of human red blood cells

Product Categories/Family for anti-SPTB antibody

Antibodies; Abs to Spectrin

Applications Tested/Suitable for anti-SPTB antibody

Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Application Notes for anti-SPTB antibody

Suitable for use in Western Blot, Immunoprecipitation and Immunocytochemistry.
Dilution: Western Blot: 1:1000

Other Notes

Small volumes of anti-SPTB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SPTB purchase

MBS609340 is an antibody targeting SPTB. Also known as Spectrin, beta, Erythrocytic (Erythroid beta-Spectrin, Spectrin beta Chain Erythrocyte, SPTB, Beta-I Spectrin, SPTB1, EL3, HS2, HSPTB1, SPH2). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for SPTB. It may not necessarily be applicable to this product.

NCBI GI #

67782321

NCBI GeneID

6710

NCBI Accession #

NP_001020029.1

UniProt Primary Accession #

P11277

UniProt Secondary Accession #

Q15510; Q15519

UniProt Related Accession #

P11277

GenBank Nucleotide #

NM_001024858.2

NCBI Official Full Name

spectrin beta chain, erythrocytic isoform a

NCBI Official Synonym Full Names

spectrin, beta, erythrocytic

NCBI Official Symbol

SPTB

NCBI Official Synonym Symbols

EL3; HS2; SPH2; HSPTB1

UniProt Protein Name

Spectrin beta chain, erythrocytic

UniProt Synonym Protein Names

Beta-I spectrin

Protein Family

Spectrin

UniProt Gene Name

SPTB

UniProt Synonym Gene Names

SPTB1

UniProt Entry Name

SPTB1_HUMAN

NCBI Protein Information

spectrin beta chain, erythrocytic; beta-I spectrin; membrane cytoskeletal protein; spectrin beta chain, erythrocyte

NCBI Summary for SPTB

This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

UniProt Comments for SPTB

SPTB1: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Defects in SPTB are the cause of elliptocytosis type 3 (EL3). EL3 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. Defects in SPTB are the cause of spherocytosis type 2 (SPH2); also known as hereditary spherocytosis type 2 (HS2). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. SPH2 is characterized by severe hemolytic anemia. Inheritance is autosomal dominant. Belongs to the spectrin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q23-q24.2

Cellular Component: spectrin; protein complex; cell surface; cytoplasm; cytosol; actin cytoskeleton

Molecular Function: actin filament binding; protein binding; structural constituent of cytoskeleton; protein heterodimerization activity; ankyrin binding; actin binding

Biological Process: axon guidance; plasma membrane organization and biogenesis; actin filament capping; hemopoiesis; porphyrin biosynthetic process

Disease: Spherocytosis, Type 2, Included

Research Articles on SPTB

1. analysis of glycosylation of erythrocyte spectrin and its modification in visceral leishmaniasis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SPTB antibody

Reference Product	PubMed Publications
ANK1 antibody	>9 publications with SPTB and ANK1
SPTA1 antibody	>7 publications with SPTB and SPTA1
SPTBN1 antibody	>1 publications with SPTB and SPTBN1

Pathways associated with anti-SPTB antibody

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Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
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Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Interaction Between L1 And Ankyrins Pathway antibodies	Interaction Between L1 And Ankyrins Pathway Diagram
L1CAM Interactions Pathway antibodies	L1CAM Interactions Pathway Diagram
NCAM Signaling For Neurite Out-growth Pathway antibodies	NCAM Signaling For Neurite Out-growth Pathway Diagram
NCAM Signaling For Neurite Out-growth Pathway antibodies	NCAM Signaling For Neurite Out-growth Pathway Diagram

Diseases associated with anti-SPTB antibody

Disease Name	Pubmed Publications
Spherocytosis, Hereditary Antibodies	>16 publications with SPTB and Spherocytosis, Hereditary
Anemia Antibodies	>15 publications with SPTB and Anemia
Anemia, Hemolytic Antibodies	>14 publications with SPTB and Anemia, Hemolytic
Inflammation Antibodies	>11 publications with SPTB and Inflammation
Elliptocytosis, Hereditary Antibodies	>6 publications with SPTB and Elliptocytosis, Hereditary
Necrosis Antibodies	>4 publications with SPTB and Necrosis
Nervous System Diseases Antibodies	>4 publications with SPTB and Nervous System Diseases
Hemolysis Antibodies	>3 publications with SPTB and Hemolysis
Neoplasms Antibodies	>2 publications with SPTB and Neoplasms
Dyslipidemias Antibodies	>1 publications with SPTB and Dyslipidemias

Organs/Tissues associated with anti-SPTB antibody

Organ/Tissue Name	Pubmed Publications
Uterus Antibodies	>12 publications with SPTB and Uterus
Placenta Antibodies	>7 publications with SPTB and Placenta
Nerve Antibodies	>2 publications with SPTB and Nerve
Muscle Antibodies	>2 publications with SPTB and Muscle
Embryonic Tissue Antibodies	>2 publications with SPTB and Embryonic Tissue
Spleen Antibodies	>2 publications with SPTB and Spleen
Brain Antibodies	>2 publications with SPTB and Brain
Heart Antibodies	>1 publications with SPTB and Heart
Lung Antibodies	>1 publications with SPTB and Lung
Mouth Antibodies	>1 publications with SPTB and Mouth