WP1066 ((2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide)

A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway.

Small volumes of WP1066 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6093881 is a biochemical targeting WP1066. Also known as WP1066 ((2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide).