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LIM Homeobox Protein 1 (LHX1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS609665

LIM homeobox protein 1 is a potential transcription factor that may play a role in differentiation and development of neural and lymphoid cells. It contains 1 homeobox DNA-binding domain and 2 LIM zinc-binding domains. The latter have a negative regulatory… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
LIM Homeobox Protein 1 (LHX1), Monoclonal Antibody
Full Product Name
LIM Homeobox Protein 1 (LIM/homeobox Protein Lhx1, Homeobox Protein 1, hLim-1, LHX1, LIM-1, LIM1)
Product Gene Name
anti-LHX1 antibody
Product Synonym Names
Anti -LIM Homeobox Protein 1 (LIM/homeobox Protein Lhx1, Homeobox Protein 1, hLim-1, LHX1, LIM-1, LIM1)
Clonality
Monoclonal
Isotype
IgG
Clone Number
9G376
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a lyophilized powder from PBS, pH7.2. Reconstitute with 100ul sterile ddH2O.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Specificity
Recognizes human LIM homeobox protein 1.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20 degree C. Aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
44,808 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (35294499..35300494). Location: 17q12
OMIM
601999
3D Structure
ModBase 3D Structure for P48742
Immunogen
Partial recombinant protein of human LIM homeobox protein 1 (aa1-101) with a GST tag.

Product Categories/Family for anti-LHX1 antibody

Antibodies; Abs to Transcription Factors; Homeobox (HOX)
Applications Tested/Suitable for anti-LHX1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-LHX1 antibody
Suitable for use in Western Blot and direct ELISA.

Other Notes

Small volumes of anti-LHX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LHX1 purchase

MBS609665 is an antibody targeting LHX1. Also known as LIM Homeobox Protein 1 (LIM/homeobox Protein Lhx1, Homeobox Protein 1, hLim-1, LHX1, LIM-1, LIM1). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for LHX1. It may not necessarily be applicable to this product.

NCBI GI #
30410785
NCBI GeneID
3975
NCBI Accession #
NP_005559.2
UniProt Primary Accession #
P48742
UniProt Secondary Accession #
Q3MIW0
UniProt Related Accession #
P48742; Q58F18
GenBank Nucleotide #
NM_005568.3
NCBI Official Full Name
LIM/homeobox protein Lhx1
NCBI Official Synonym Full Names
LIM homeobox 1
NCBI Official Symbol
LHX1
NCBI Official Synonym Symbols
LIM1; LIM-1; MGC126723; MGC138141
UniProt Protein Name
LIM/homeobox protein Lhx1
UniProt Synonym Protein Names
Homeobox protein Lim-1
Protein Family
LIM homeobox transcription factor
UniProt Gene Name
LHX1
UniProt Synonym Gene Names
LIM-1; LIM1
UniProt Entry Name
LHX1_HUMAN
NCBI Protein Information
LIM/homeobox protein Lhx1; OTTHUMP00000164082; LIM homeobox protein 1; homeobox protein Lim-1

NCBI Summary for LHX1

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract. [provided by RefSeq]
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UniProt Comments for LHX1

LHX1: Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.

Protein type: Transcription factor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: protein complex; nucleus

Molecular Function: zinc ion binding; sequence-specific DNA binding; transcription factor activity; transcription corepressor activity

Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; motor axon guidance; forebrain regionalization; embryonic pattern specification; uterus development; pronephros development; post-embryonic development; anterior/posterior pattern formation; cell-cell signaling; ectoderm formation; ureteric bud development; anatomical structure formation; cerebellum development; kidney development; fallopian tube development; cervix development; nervous system development; anatomical structure morphogenesis; vagina development; ventral spinal cord development; gastrulation with mouth forming second; embryonic viscerocranium morphogenesis; somite rostral/caudal axis specification; pattern specification process; Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation; organ morphogenesis; telencephalon development; positive regulation of embryonic development; dorsal/ventral pattern formation; ureteric bud branching; endoderm formation; regulation of gene expression; embryonic retina morphogenesis in camera-type eye; cerebellar Purkinje cell differentiation; spinal cord association neuron differentiation; negative regulation of transcription, DNA-dependent; urogenital system development; anterior/posterior axis specification
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Research Articles on LHX1

1. findings establish that the developmental marker Lim1 acts as an oncogene in cancer cells and targeting Lim1 may constitute an innovative therapeutic intervention in human lear cell carcinoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LHX1 antibody

 Reference Product  PubMed Publications
 RLIM antibody  >4 publications with LHX1 and RLIM
 ISL1 antibody  >4 publications with LHX1 and ISL1

Diseases associated with anti-LHX1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >9 publications with LHX1 and Neoplasms
 Female Urogenital Diseases Antibodies  >6 publications with LHX1 and Female Urogenital Diseases
 Kidney Diseases Antibodies  >4 publications with LHX1 and Kidney Diseases
 Craniofacial Abnormalities Antibodies  >3 publications with LHX1 and Craniofacial Abnormalities
 Leukemia Antibodies  >3 publications with LHX1 and Leukemia
 Wilms Tumor Antibodies  >2 publications with LHX1 and Wilms Tumor
 Pancreatic Neoplasms Antibodies  >2 publications with LHX1 and Pancreatic Neoplasms
 Limb Deformities, Congenital Antibodies  >1 publications with LHX1 and Limb Deformities, Congenital
 Eye Abnormalities Antibodies  >1 publications with LHX1 and Eye Abnormalities
 Leukemia, Myeloid Antibodies  >1 publications with LHX1 and Leukemia, Myeloid

Organs/Tissues associated with anti-LHX1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >36 publications with LHX1 and Brain
 Embryonic Tissue Antibodies  >32 publications with LHX1 and Embryonic Tissue
 Kidney Antibodies  >26 publications with LHX1 and Kidney
 Uterus Antibodies  >4 publications with LHX1 and Uterus
 Cervix Antibodies  >1 publications with LHX1 and Cervix
 Prostate Antibodies  >1 publications with LHX1 and Prostate
 Thyroid Antibodies  >1 publications with LHX1 and Thyroid
 Ovary Antibodies  >1 publications with LHX1 and Ovary
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