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AIF1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS609673

AIF-1 is a 17kD IFN-gamma inducible Ca2+-binding EF-hand protein, associated with chronic inflammatory processes. AIF-1 is constitutively expressed in lymphatic tissue and is up-regulated in monocytes/macrophages under various pathological conditions such as… More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
AIF1, Monoclonal Antibody
Full Product Name
AIF1 (Allograft Inflammatory Factor 1, AIF-1, DASS-82G15.2, G1, IBA1, IRT-1, Em:AF129756.17, Interferon gamma Responsive Transcript, IRT-1, Ionized Calcium-binding Adapter Molecule, Protein G1)
Product Gene Name
anti-AIF1 antibody
Product Synonym Names
Anti -AIF1 (Allograft Inflammatory Factor 1, AIF-1, DASS-82G15.2, G1, IBA1, IRT-1, Em:AF129756.17, Interferon gamma Responsive Transcript, IRT-1, Ionized Calcium-binding Adapter Molecule, Protein G1)
Clonality
Monoclonal
Isotype
IgG1, k
Clone Number
2A2-B6
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Purified
Purified.
Specificity
Recognizes human AIF1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
10,455 Da
3D Structure
ModBase 3D Structure for Q9UIV4
Immunogen
AIF1 (AAH09474, 1-148aa) full length recombinant protein with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-AIF1 antibody

Antibodies; Abs to Actin Related Proteins
Applications Tested/Suitable for anti-AIF1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-AIF1 antibody
Suitable for use in ELISA and Western Blot.

Testing Data of anti-AIF1 antibody

Detection limit for recombinant GST tagged AIF1 is 0.03ng/ml using MBS609673 as a capture antibody.
Mouse Anti-AIF1 Monoclonal Antibody – Cat# MBS609673

Western Blot (WB) of anti-AIF1 antibody

Western Blot analysis of AIF1 expression in K-562 using MBS609673.
Mouse Anti-AIF1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS609673

Other Notes

Small volumes of anti-AIF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AIF1 purchase

MBS609673 is an antibody targeting AIF1. Also known as AIF1 (Allograft Inflammatory Factor 1, AIF-1, DASS-82G15.2, G1, IBA1, IRT-1, Em:AF129756.17, Interferon gamma Responsive Transcript, IRT-1, Ionized Calcium-binding Adapter Molecule, Protein G1). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for AIF1. It may not necessarily be applicable to this product.

NCBI GI #
49457302
UniProt Primary Accession #
Q9UIV4
NCBI Official Full Name
AIF1
UniProt Protein Name
AIF1 protein
Protein Family
Allograft inflammatory factor
UniProt Gene Name
AIF1
UniProt Entry Name
Q9UIV4_HUMAN

NCBI Summary for AIF1

This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
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UniProt Comments for AIF1

AIF1: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: perinuclear region of cytoplasm; lamellipodium; cytoplasm; perikaryon; actin filament; cytosol; nucleus; phagocytic cup

Molecular Function: actin filament binding; calcium ion binding

Biological Process: actin filament bundle formation; positive regulation of nitric oxide biosynthetic process; negative regulation of smooth muscle cell proliferation; positive regulation of smooth muscle cell proliferation; microglial cell activation; Rac protein signal transduction; cellular response to hormone stimulus; actin filament polymerization; positive regulation of muscle hyperplasia; cellular response to extracellular stimulus; positive regulation of T cell proliferation; positive regulation of protein amino acid phosphorylation; response to axon injury; response to electrical stimulus; inflammatory response; phagocytosis, engulfment; negative regulation of apoptosis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AIF1 antibody

 Reference Product  PubMed Publications
 FLNA antibody  >12 publications with AIF1 and FLNA

Pathways associated with anti-AIF1 antibody

 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram

Diseases associated with anti-AIF1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >157 publications with AIF1 and Nervous System Diseases
 Inflammation Antibodies  >68 publications with AIF1 and Inflammation
 Autoimmune Diseases Antibodies  >29 publications with AIF1 and Autoimmune Diseases
 Neoplasms Antibodies  >16 publications with AIF1 and Neoplasms
 Skin Diseases Antibodies  >15 publications with AIF1 and Skin Diseases
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >13 publications with AIF1 and Encephalomyelitis, Autoimmune, Experimental
 Drug Toxicity Antibodies  >10 publications with AIF1 and Drug Toxicity
 Poisoning Antibodies  >9 publications with AIF1 and Poisoning
 Edema Antibodies  >7 publications with AIF1 and Edema
 Arteriosclerosis Antibodies  >6 publications with AIF1 and Arteriosclerosis

Organs/Tissues associated with anti-AIF1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >186 publications with AIF1 and Brain
 Blood Antibodies  >76 publications with AIF1 and Blood
 Vascular Antibodies  >42 publications with AIF1 and Vascular
 Muscle Antibodies  >28 publications with AIF1 and Muscle
 Bone Marrow Antibodies  >18 publications with AIF1 and Bone Marrow
 Heart Antibodies  >13 publications with AIF1 and Heart
 Skin Antibodies  >11 publications with AIF1 and Skin
 Eye Antibodies  >11 publications with AIF1 and Eye
 Embryonic Tissue Antibodies  >9 publications with AIF1 and Embryonic Tissue
 Kidney Antibodies  >7 publications with AIF1 and Kidney
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