Caspase 9, P35 (CASP9) Antibody – Rabbit Polyclonal

Apoptosis or programmed cell death is a fundamental cellular process that is essential for normal tissue development and abnormal growth such as cancer, neurodegeneration, autoimmune diseases, and angiogenesis, etc. Apoptosis is driven by specialized proteases known as caspases. After the initial discovery of the first mammalian caspase 1 or ICE (interleukin 1 beta converting enzyme), a growing family of caspases 1-14 have been cloned and characterized. Caspases are synthesized as inactive zymogen or proenzyme forms (30-55kD), which upon apoptotic stimulation are proteolytically processed (self or by other proteins) in a sequential manner into their active heterotetrameric forms. The processed form consists of large subunit (17-20kD) and a small (10-12kD) subunits, which may associate to form an active enzyme. Functionally active caspases initiate a proteolytic cascade, capable of cleaving and activating numerous cellular targets including PARP, G4-GDI, DFF, MEKK, etc. On a functional basis, two categories of caspases have been defined: the initiator caspases (caspases-8, -9, and -10) are activated in the earlier phases of apoptosis, whereas the executioner caspases (caspases-3, -6, and -7) are activated by initiator caspases and are responsible for dismantling cellular components. Caspases are widely distributed in various tissues and cells.

• 1. Duan H et al (196) JBC 271, 16720; Srinivasula SM et al (1996) JBC 271, 27099; Angelastro JM et al (2001) JBC 276, 12190

Small volumes of anti-CASP9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS610075 is an antibody targeting CASP9. Also known as Anti - Caspase 9, p35 (ICE-LAP6, Mch6, Apaf 3). Reactive in Human. Host: Rabbit
Source: Human.